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Bone marrow adiposity during pathologic bone loss: molecular mechanisms underlying the cellular events
- Source :
- Journal of Molecular Medicine. 100:167-183
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Bone marrow (BM) is a heterogeneous niche where bone marrow stromal cells (BMSCs), osteoblasts, osteoclasts, adipocytes, hematopoietic cells, and immune cells coexist. The cellular composition of BM changes with various pathophysiological states. A reduction in osteoblast number and a concomitant increase in adipocyte number in aging and pathological conditions put bone marrow adipose tissue (BMAT) into spotlight. Accumulating evidence strongly supports that an overwhelming production of BMAT is a major contributor to bone loss disorders. Therefore, BMAT-targeted therapy can be an efficient and feasible intervention for osteoporosis. However, compared to blocking bone-destroying molecules produced by BMAT, suppressing BMAT formation is theoretically a more effective and fundamental approach in treating osteoporotic bone diseases. Thus, a deep insight into the molecular basis underlying increased BM adiposity during pathologic bone loss is critical to formulate strategies for therapeutically manipulating BMAT. In this review, we comprehensively summarize the molecular mechanisms involved in adipocyte differentiation of BMSCs as well as the interaction between bone marrow adipocytes and osteoclasts. More importantly, we further discuss the potential clinical implications of therapeutically targeting the upstream of BMAT formation in bone loss diseases.
- Subjects :
- RNA, Untranslated
Stromal cell
Osteoporosis
Osteoclasts
Adipose tissue
Epigenesis, Genetic
chemistry.chemical_compound
Bone Marrow
Adipocyte
Drug Discovery
Adipocytes
Animals
Humans
Medicine
Bone Resorption
Genetics (clinical)
Adiposity
Adipogenesis
business.industry
Mesenchymal Stem Cells
Osteoblast
medicine.disease
Molecular medicine
Haematopoiesis
medicine.anatomical_structure
chemistry
Cancer research
Molecular Medicine
Bone marrow
business
Subjects
Details
- ISSN :
- 14321440 and 09462716
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular Medicine
- Accession number :
- edsair.doi.dedup.....5c3ce0d9dcd705647babe0073beaf5f3