Back to Search
Start Over
Diagnostic accuracy of swept source optical coherence tomography classification algorithms for detection of gonioscopic angle closure
- Source :
- British Journal of Ophthalmology. 106:1716-1721
- Publication Year :
- 2021
- Publisher :
- BMJ, 2021.
-
Abstract
- PurposeTo evaluate the performance of swept source optical coherence tomography (SS-OCT) to detect gonioscopic angle closure using different classification algorithms.MethodsThis was a cross-sectional study of 2028 subjects without ophthalmic symptoms recruited from a community-based clinic. All subjects underwent gonioscopy and SS-OCT (Casia, Tomey Corporation, Nagoya, Japan) under dark room conditions. For each eye, 8 out of 128 frames (22.5° interval) were selected to measure anterior chamber parameters namely anterior chamber width, depth, area and volume (ACW, ACD, ACA, and ACV), lens vault (LV), iris curvature (IC), iris thickness (IT) from 750 µm and 2000 µm from the scleral spur, iris area and iris volume. Five diagnostic algorithms—stepwise logistic regression, random forest, multivariate adaptive regression splines, recursive partitioning and Naïve Bayes were evaluated for detection of gonioscopic angle closure (defined as ≥2 closed quadrants). The performance of the horizontal frame was compared with that of other meridians.ResultsData from 1988 subjects, including 143 (7.2%) with gonioscopic angle closure, were available for analysis. They were divided into two groups: training (1391, 70%) and validation (597, 30%). The best algorithm for detecting gonioscopic angle closure was stepwise logistic regression with an area under the curve of 0.91 (95% CI 0.88 to 0.93) using all parameters, and 0.88 (95% CI 0.82 to 0.93) using only ACA, LV and IC of the horizontal meridian scan.ConclusionsA stepwise logistic regression model incorporating SS-OCT measurements has a high diagnostic ability to detect gonioscopic angle closure.
- Subjects :
- Gonioscopy
Iris
Glaucoma
Scleral spur
Recursive partitioning
Cellular and Molecular Neuroscience
Optical coherence tomography
Anterior Eye Segment
Humans
Medicine
Intraocular Pressure
Multivariate adaptive regression splines
medicine.diagnostic_test
business.industry
Bayes Theorem
Stepwise regression
medicine.disease
Sensory Systems
Random forest
Ophthalmology
Cross-Sectional Studies
medicine.anatomical_structure
Glaucoma, Angle-Closure
business
Nuclear medicine
Tomography, Optical Coherence
Algorithms
Subjects
Details
- ISSN :
- 14682079 and 00071161
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- British Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....5c11b6ab12f7a4f8af504944ae85e3b6