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HCV genotype 3 and squamous cell carcinoma antigen (SCCA)-IgM are independently associated with histological features of NASH in HCV-infected patients
- Publication Year :
- 2015
-
Abstract
- Nonalcoholic steatohepatitis (NASH) enhances the risk of progressive liver disease. In chronic hepatitis C (CHC), liver steatosis is frequent, especially in genotype 3, but its clinical significance is debated. As squamous cell carcinoma antigen (SCCA)-IgM has been associated with advanced liver disease and risk of tumour development, we evaluated its occurrence in CHC and the possible relation with NASH at liver biopsy. Using a validated ELISA, serum SCCA-IgM was measured in 91 patients with CHC at the time of liver biopsy performed before antiviral treatment, at the end of treatment and 6 months thereafter, and in 93 HCV-negative patients with histological diagnosis of nonalcoholic fatty liver disease, as controls. SCCA-IgM was detected in 33% of CHC patients and in 4% of controls. This biomarker was found more elevated in CHC patients with histological NASH, and at multivariate analysis, SCCA-IgM and HCV genotype 3 were independently associated with NASH [OR (95% CI): 6.94 (1.21-40) and 27.02 (4.44-166.6)]. As predictors of NASH, HCV genotype 3 and SCCA-IgM had a specificity and a sensitivity of 97% and 44%, and of 95% and 27%, respectively. PPV and NPV were 80% and 86% for HCV genotype 3 vs 73% and 72% for SCCA-IgM. In patients with sustained virologic response to therapy, SCCA-IgM levels decreased significantly, while these remained unchanged in nonresponders. In conclusion, SCCA-IgM is detectable in one-third of patients with CHC and significantly correlates with histological NASH.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Adolescent
Genotype
Antibodies, Neoplasm
Hepacivirus
HCV genotype 3
Enzyme-Linked Immunosorbent Assay
SCCA-IgM
Gastroenterology
Antibodies
Liver disease
Young Adult
Antigens, Neoplasm
Non-alcoholic Fatty Liver Disease
Internal medicine
nonalcoholic steatohepatitis
Aged
Hepatitis C, Chronic
Humans
Immunoglobulin M
Middle Aged
Serpins
Hepatology
Infectious Diseases
Virology
Nonalcoholic fatty liver disease
medicine
Clinical significance
Antigens
Chronic
medicine.diagnostic_test
biology
medicine.disease
biology.organism_classification
Hepatitis C
digestive system diseases
Liver biopsy
Biomarker (medicine)
Neoplasm
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....5bfdeea7f00336e4e8b99e29b15b3a5d