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Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
- Source :
- Chen, Y C, Kraft, P, Bretsky, P, Ketkar, S, Hunter, D J, Albanes, D, Altshuler, D, Andriole, G, Berg, C D, Boeing, H, Burtt, N, Bueno-de-Mesquita, B, Cann, H, Canzian, F, Chanock, S, Dunning, A, Feigelson, H S, Freedman, M, Gaziano, J M, Giovannucci, E, Sanchez, M J, Haiman, C A, Hallmans, G, Hayes, R B, Henderson, B E, Hirschhorn, J, Kaaks, R, Key, T J, Kolonel, L N, Lemarchand, L, Ma, J, Overvad, K, Palli, D, Pharaoh, P, Pike, M, Riboli, E, Rodriguez, C, Setiawan, V W, Stampfer, M, Stram, D O, Thomas, G, Thun, M J, Travis, R C, Virtamo, J, Trichopoulou, A, Wacholder, S & Weinstein, S J 2007, ' Sequence Variants of Estrogen Receptor {beta} and Risk of Prostate Cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium ', Cancer Epidemiologicl Biomarkers and Prevention, vol. 16, no. 10, pp. 1973-81 ., Aarhus University
- Publication Year :
- 2007
-
Abstract
- Background: Estrogen receptor β (ESR2) may play a role in modulating prostate carcinogenesis through the regulation of genes related to cell proliferation and apoptosis. Methods: We conducted nested case-control studies in the Breast and Prostate Cancer Cohort Consortium (BPC3) that pooled 8,323 prostate cancer cases and 9,412 controls from seven cohorts. Whites were the predominant ethnic group. We characterized genetic variation in ESR2 by resequencing exons in 190 breast and prostate cancer cases and genotyping a dense set of single nucleotide polymorphisms (SNP) spanning the locus in a multiethnic panel of 349 cancer-free subjects. We selected four haplotype-tagging SNPs (htSNP) to capture common ESR2 variation in Whites; these htSNPs were then genotyped in all cohorts. Conditional logistic regression models were used to assess the association between sequence variants of ESR2 and the risk of prostate cancer. We also investigated the effect modification by age, body mass index, and family history, as well as the association between sequence variants of ESR2 and advanced-stage (≥T3b, N1, or M1) and high-grade (Gleason sum ≥8) prostate cancer, respectively. Results: The four tag SNPs in ESR2 were not significantly associated with prostate cancer risk, individually. The global test for the influence of any haplotype on the risk of prostate cancer was not significant (P = 0.31). However, we observed that men carrying two copies of one of the variant haplotypes (TACC) had a 1.46-fold increased risk of prostate cancer (99% confidence interval, 1.06-2.01) compared with men carrying zero copies of this variant haplotype. No SNPs or haplotypes were associated with advanced stage or high grade of prostate cancer. Conclusion: In our analysis focused on genetic variation common in Whites, we observed little evidence for any substantial association of inherited variation in ESR2 with risk of prostate cancer. A nominally significant (P < 0.01) association between the TACC haplotype and prostate cancer risk under the recessive model could be a chance finding and, in any event, would seem to contribute only slightly to the overall burden of prostate cancer. (Cancer Epidemiol Biomarkers Prev 2007;16(10):1973–81)
- Subjects :
- Oncology
Male
medicine.medical_specialty
Genotype
Epidemiology
Mammary gland
Breast Neoplasms
Polymorphism, Single Nucleotide
Risk Assessment
Cohort Studies
Prostate cancer
Breast cancer
Internal medicine
Epidemiology of cancer
medicine
Estrogen Receptor beta
Humans
Genetic Predisposition to Disease
Risk factor
Estrogen receptor beta
Aged
Neoplasm Staging
Gynecology
business.industry
Cancer
Genetic Variation
Prostatic Neoplasms
Exons
Sequence Analysis, DNA
medicine.disease
Prognosis
medicine.anatomical_structure
Haplotypes
Case-Control Studies
Cohort
Female
business
Subjects
Details
- ISSN :
- 10559965
- Volume :
- 16
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Accession number :
- edsair.doi.dedup.....5bf1fccf118faa1cd416fd53f4660835