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Intravenous Ferric Carboxymaltose in Children with Iron Deficiency Anemia Who Respond Poorly to Oral Iron
- Source :
- The Journal of pediatrics. 180
- Publication Year :
- 2016
-
Abstract
- Objective To assess the benefits and risks of intravenous (IV) ferric carboxymaltose (FCM) in children with iron deficiency anemia (IDA). Study design In a retrospective cohort study of patients seen at our center, we identified all FCM infusions in children with IDA over a 12-month period through a query of pharmacy records. Clinical data, including hematologic response and adverse effects, were extracted from the electronic medical record. Results A total of 116 IV FCM infusions were administered to 72 patients with IDA refractory to oral iron treatment (median age, 13.7 years; range, 9 months to 18 years). Median preinfusion and postinfusion hemoglobin values were 9.1 g/dL and 12.3 g/dL, respectively (at 4-12 weeks after the initial infusion; n = 53). Sixty-five patients (84%) experienced no adverse effects. Minor transient complications were encountered during or immediately after 7 infusions. Conclusion FCM administered as a short IV infusion without a test dose proved to be safe and highly effective in a small yet diverse population of infants, children, and adolescents with IDA refractory to oral iron therapy.
- Subjects :
- Male
medicine.medical_specialty
Pediatrics
Adolescent
Iron
Administration, Oral
030204 cardiovascular system & hematology
Inflammatory bowel disease
Ferric Compounds
FERRIC CARBOXYMALTOSE
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Refractory
medicine
Humans
Adverse effect
Child
Infusions, Intravenous
Maltose
Retrospective Studies
Anemia, Iron-Deficiency
business.industry
Infant
Retrospective cohort study
medicine.disease
Hematologic Response
Surgery
Treatment Outcome
Iron-deficiency anemia
030220 oncology & carcinogenesis
Child, Preschool
Pediatrics, Perinatology and Child Health
Female
Hemoglobin
business
Subjects
Details
- ISSN :
- 10976833
- Volume :
- 180
- Database :
- OpenAIRE
- Journal :
- The Journal of pediatrics
- Accession number :
- edsair.doi.dedup.....5bf039d536ffd4d0f37761b904f9edaa