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Aspirin Can Elicit The Recurrence of Gastric Ulcer Induced with Acetic Acid in Rats
- Source :
- Cellular Physiology and Biochemistry. 20:205-212
- Publication Year :
- 2007
- Publisher :
- S. Karger AG, 2007.
-
Abstract
- This study was supported by grants of New Ideas Capability for Backbone Teachers in Universities of Heilongjiang and of Scientific Research foundation in Qiqihar Medical College.Ulcer recurrence and poor healing may be critically important to the development of serious gastrointestinal complications in patients with long-term non-steroid anti-inflammatory drugs (NSAIDs). The present study is to investigate the effects of aspirin on ulcer recurrence and healing quality and to explore the mechanism.Gastric ulcers were induced with acetic acid in rats; aspirin was administrated by gavage from day 25 to day 54 after ulcer induction. The gastric juice volume, pH, gastric mucus, gastric mucosal blood flow (GMBF) and prostaglandin E(2) (PGE(2)) were measured. The mRNA transcription of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) were analyzed with RT-PCR and protein expression with Western blot.The gastric juice volume was significantly increased in aspirin group compared with those of fasting or saline control groups (P0.01); while the pH, mucus, GMBF and PGE(2) were significantly decreased in aspirin treated rats compared with those of other two groups (P0.01). COX-2, evaluated with mRNA and protein expression, was significantly augmented in aspirin group compared with others. The quality of ulcer healing (QOUH) in Aspirin group was poorer than that of fasting or saline control groups.Aspirin enhance the recurrence of gastric ulcer. The inhibition of cycloxygenase, mucus secretion and mucosal blood flow may be involved. Aspirin also impair the quality of ulcer healing.
- Subjects :
- Male
Ulcer healing
medicine.medical_specialty
Physiology
MEDLINE
Dinoprostone
Recurrence
Internal medicine
medicine
Animals
Base sequence
RNA, Messenger
Stomach Ulcer
Rats, Wistar
Acetic Acid
DNA Primers
Aspirin
Gastric Juice
Base Sequence
biology
business.industry
Anti-Inflammatory Agents, Non-Steroidal
Membrane Proteins
Hydrogen-Ion Concentration
Rats
Surgery
Cyclooxygenase 2
Gastric Mucosa
Regional Blood Flow
Cyclooxygenase 1
biology.protein
Cyclooxygenase
business
medicine.drug
Subjects
Details
- ISSN :
- 14219778 and 10158987
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Cellular Physiology and Biochemistry
- Accession number :
- edsair.doi.dedup.....5bec242599d4de9fc60364b42e5dca63