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Compensatory pathways in oncogenic kinase signaling and resistance to targeted therapies: six degrees of separation
- Source :
- Cancer discovery. 2(10)
- Publication Year :
- 2012
-
Abstract
- Summary: The efficacy of targeted therapies against mutationally activated kinases is typically limited by the engagement of growth-promoting cues that compensate for inhibition of the targeted kinase. Initial studies have highlighted the contribution of genomic alterations, functional characteristics, and signaling feedback loops—all intrinsic to cancer cells—in sustaining such substitute activities. New evidence now indicates that the relative expression of growth factor ligands produced by the tumor microenvironment can relay redundant survival pathways, which may broadly impair responsiveness to kinase inhibitors. Cancer Discov; 2(10); 876–80. ©2012 AACR.
- Subjects :
- medicine.medical_treatment
EGFR
Biology
Kinase signaling
Neoplasms
medicine
BREAST-CANCER
Humans
INHIBITORS
HETEROGENEITY
FEEDBACK
Molecular Targeted Therapy
Protein Kinase Inhibitors
Tumor microenvironment
Kinase
Growth factor
Cancer
medicine.disease
Cell biology
Survival pathways
Oncology
Drug Resistance, Neoplasm
Intercellular Signaling Peptides and Proteins
Protein Kinases
Signal Transduction
Subjects
Details
- ISSN :
- 21598290
- Volume :
- 2
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Cancer discovery
- Accession number :
- edsair.doi.dedup.....5be8c967379a61fae80374bb823ec909