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Adrenomedullin and nitric oxide in children with detrusor instability
- Source :
- Scopus-Elsevier
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- Detrusor instability (DI) and detrusor-external sphincter dyssynergia lead to poor bladder emptying and high bladder pressure. Recent results indicate that nitric oxide (NO) is an important transmitter or messenger molecule in autonomic neurotransmission. Adrenomedullin (AM) is a potent vasodilator and natriuretic peptide, originally purified from human pheochromocytoma. Since NO and AM have vasodilatory effects on smooth muscles, we considered them to be of interest in children with DI. We determined the tissue levels of NO and AM in 14 children with DI, and compared these with 6 children with normal bladder activity. Bladder biopsy total nitrite levels (nmol/g tissue) were decreased in children with DI (10.69+/-0.91 vs. 12.83+/-0.98, P0.01). However, AM levels (pmol/g tissue) were increased in the same patients (48.84+/-3.52 vs. 28.79+/-1.53, P0.001). According to our results, decreased NO production probably has a role in the pathophysiology of DI, although increased AM appears to be compensatory. NO may provide a therapeutic target in clinical situations related to DI. However, the functional significance of AM and NO in bladder smooth muscle remains to be determined by further detailed studies.
- Subjects :
- Male
Detrusor muscle
medicine.medical_specialty
medicine.drug_class
Urinary Bladder
Vasodilation
Nitric Oxide
Nitric oxide
Dyssynergia
Adrenomedullin
chemistry.chemical_compound
Atrial natriuretic peptide
Internal medicine
medicine
Natriuretic peptide
Humans
Child
business.industry
Muscle, Smooth
Urination Disorders
Pathophysiology
Urodynamics
Endocrinology
medicine.anatomical_structure
chemistry
Nephrology
Child, Preschool
Pediatrics, Perinatology and Child Health
Female
Peptides
business
Subjects
Details
- ISSN :
- 1432198X and 0931041X
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Pediatric Nephrology
- Accession number :
- edsair.doi.dedup.....5be2c95c5cfa306e4d8a94a98e51763c