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The unmeasured burden: Contribution of depression and psychological stress to patient-reported outcomes in atrial fibrillation
- Source :
- Int J Cardiol
- Publication Year :
- 2019
-
Abstract
- Introduction Patient-reported outcomes are routinely assessed in atrial fibrillation (AF) to evaluate efficacy of treatment and as clinical trial outcomes. The relation of depression to such measures has had limited study in AF. Methods In a cohort receiving treatment for AF, we assessed depression with the Patient Health Questionniare-9 (PHQ; 0–4, normal range; 5–9, mild depression; ≥10 moderate depression). We related depression to disease-specific quality of life with the AF Effect on QualiTy of life (AFEQT, range 0–100) and the Global Perceived Stress Scale (GPPS, range 0–24) in multivariable-adjusted models. Results In 260 individuals (age 71.7 ± 10.1, 44.6% women) with AF, 51 (26.1%) had PHQ scores ≥5 and 17 (6.5%) ≥10. AFEQT scores decreased progressively with depression severity (normal range PHQ, 81.4 ± 14.1; mild depression, 65.8 ± 17.1; moderate depression, 50.6 ± 19.3). Individuals without depression had lower GPPS scores (3.0 ± 2.6) than those with mild (4.9 ± 2.5) or moderate (8.9 ± 4.0) depression. In multivariable-adjusted models mild depression was associated with a 12.1-point (95% confidence interval [CI], −17.2 to −6.9) decrease in AFEQT and 1.9-point (95% CI, 1.1 to 2.7) increase in GPSS, while moderate depression a 27.7-point (95% CI, −35.5 to −19.8) decrease in AFEQT and 5.5-point (95% CI, 4.2 to 6.8) increase in GPSS, relative to normal range PHQ. Regression analyses confirmed significant correlations between depression and AFEQT and GPPS scores in multivariable-adjusted models. Conclusions We determined that depression is associated with a step-wise, progressively adverse change in patient-centered outcomes in individuals with AF. Our findings suggest the importance of assessing depression in the evaluation of AF. Subject term list: health services, atrial fibrillation, risk factors
- Subjects :
- Male
medicine.medical_specialty
Perceived Stress Scale
030204 cardiovascular system & hematology
medicine.disease_cause
Article
03 medical and health sciences
0302 clinical medicine
Quality of life
Risk Factors
Internal medicine
Atrial Fibrillation
medicine
Psychological stress
Humans
030212 general & internal medicine
Patient Reported Outcome Measures
Depression (differential diagnoses)
Aged
business.industry
Depression
Atrial fibrillation
medicine.disease
Confidence interval
Clinical trial
Cohort
Disease Progression
Quality of Life
Female
Cardiology and Cardiovascular Medicine
business
Stress, Psychological
Subjects
Details
- ISSN :
- 18741754
- Volume :
- 302
- Database :
- OpenAIRE
- Journal :
- International journal of cardiology
- Accession number :
- edsair.doi.dedup.....5bdca6248e5df471dfc9887dc4e0c4a5