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Guanylin peptides: cyclic GMP signaling mechanisms
- Source :
- Brazilian Journal of Medical and Biological Research v.32 n.11 1999, Brazilian Journal of Medical and Biological Research, Associação Brasileira de Divulgação Científica (ABDC), instacron:ABDC, Brazilian Journal of Medical and Biological Research, Vol 32, Iss 11, Pp 1329-1336 (1999), Brazilian Journal of Medical and Biological Research, Volume: 32, Issue: 11, Pages: 1329-1336, Published: NOV 1999
- Publication Year :
- 1999
-
Abstract
- Guanylate cyclases (GC) serve in two different signaling pathways involving cytosolic and membrane enzymes. Membrane GCs are receptors for guanylin and atriopeptin peptides, two families of cGMP-regulating peptides. Three subclasses of guanylin peptides contain one intramolecular disulfide (lymphoguanylin), two disulfides (guanylin and uroguanylin) and three disulfides (E. coli stable toxin, ST). The peptides activate membrane receptor-GCs and regulate intestinal Cl- and HCO3- secretion via cGMP in target enterocytes. Uroguanylin and ST also elicit diuretic and natriuretic responses in the kidney. GC-C is an intestinal receptor-GC for guanylin and uroguanylin, but GC-C may not be involved in renal cGMP pathways. A novel receptor-GC expressed in the opossum kidney (OK-GC) has been identified by molecular cloning. OK-GC cDNAs encode receptor-GCs in renal tubules that are activated by guanylins. Lymphoguanylin is highly expressed in the kidney and heart where it may influence cGMP pathways. Guanylin and uroguanylin are highly expressed in intestinal mucosa to regulate intestinal salt and water transport via paracrine actions on GC-C. Uroguanylin and guanylin are also secreted from intestinal mucosa into plasma where uroguanylin serves as an intestinal natriuretic hormone to influence body Na+ homeostasis by endocrine mechanisms. Thus, guanylin peptides control salt and water transport in the kidney and intestine mediated by cGMP via membrane receptors with intrinsic guanylate cyclase activity.
- Subjects :
- kidney
Receptors, Peptide
Physiology
Guanylin
Immunology
Biophysics
Receptors, Enterotoxin
Receptors, Cell Surface
Biology
Kidney
Biochemistry
Gastrointestinal Hormones
chemistry.chemical_compound
Mice
Intestinal mucosa
Animals
Secretion
RNA, Messenger
General Pharmacology, Toxicology and Pharmaceutics
Intestinal Mucosa
Receptor
Natriuretic Peptides
lcsh:QH301-705.5
intestine
Cyclic GMP
lcsh:R5-920
Water transport
General Neuroscience
Guanylate cyclase activity
Cell Biology
General Medicine
Opossums
chloride secretion
Rats
guanylate cyclase
chemistry
lcsh:Biology (General)
Receptors, Guanylate Cyclase-Coupled
Guanylate Cyclase
Signal transduction
sodium excretion
lcsh:Medicine (General)
Peptides
hormones, hormone substitutes, and hormone antagonists
Uroguanylin
Signal Transduction
Subjects
Details
- ISSN :
- 0100879X
- Volume :
- 32
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
- Accession number :
- edsair.doi.dedup.....5bd581f20f2e2018ea129923dd158440