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Effect of vitamin D supplementation on markers of vascular function: a systematic review and individual participant meta‐analysis
- Source :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Beveridge, L A, Khan, F, Struthers, A D, Armitage, J, Barchetta, I, Bressendorff, I, Cavallo, M G, Clarke, R, Dalan, R, Dreyer, G, Gepner, A D, Forouhi, N G, Harris, R A, Hitman, G A, Larsen, T, Khadgawat, R, Marckmann, P, Mose, F H, Pilz, S, Scholze, A, Shargorodsky, M, Sokol, S I, Stricker, H, Zoccali, C & Witham, M D 2018, ' Effect of Vitamin D Supplementation on Markers of Vascular Function : A Systematic Review and Individual Participant Meta-Analysis ', Journal of the American Heart Association, vol. 7, no. 11, e008273 . https://doi.org/10.1161/JAHA.117.008273, Beveridge, L A, Khan, F, Struthers, A D, Armitage, J, Barchetta, I, Bressendorff, I, Cavallo, M G, Clarke, R, Dalan, R, Dreyer, G, Gepner, A D, Forouhi, N G, Harris, R A, Hitman, G A, Larsen, T, Khadgawat, R, Marckmann, P, Mose, F H, Pilz, S, Scholze, A, Shargorodsky, M, Sokol, S I, Stricker, H, Zoccali, C & Witham, M D 2018, ' Effect of vitamin D supplementation on markers of vascular function : A systematic review and individual participant meta-analysis ', Journal of the American Heart Association, vol. 7, no. 11, e008273 . https://doi.org/10.1161/JAHA.117.008273
- Publication Year :
- 2019
- Publisher :
- American Heart Association, 2019.
-
Abstract
- Background: Low 25‐hydroxyvitamin D levels are associated with an increased risk of cardiovascular events, but the effect of vitamin D supplementation on markers of vascular function associated with major adverse cardiovascular events is unclear.Methods and Results: We conducted a systematic review and individual participant meta‐analysis to examine the effect of vitamin D supplementation on flow‐mediated dilatation of the brachial artery, pulse wave velocity, augmentation index, central blood pressure, microvascular function, and reactive hyperemia index. MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials, and http://www.ClinicalTrials.gov were searched until the end of 2016 without language restrictions. Placebo‐controlled randomized trials of at least 4 weeks duration were included. Individual participant data were sought from investigators on included trials. Trial‐level meta‐analysis was performed using random‐effects models; individual participant meta‐analyses used a 2‐stage analytic strategy, examining effects in prespecified subgroups. 31 trials (2751 participants) were included; 29 trials (2641 participants) contributed data to trial‐level meta‐analysis, and 24 trials (2051 participants) contributed to individual‐participant analyses. Vitamin D3 daily dose equivalents ranged from 900 to 5000 IU; duration was 4 weeks to 12 months. Trial‐level meta‐analysis showed no significant effect of supplementation on macrovascular measures (flow‐mediated dilatation, 0.37% [95% confidence interval, −0.23 to 0.97]; carotid‐femoral pulse wave velocity, 0.00 m/s [95% confidence interval, −0.36 to 0.37]); similar results were obtained from individual participant data. Microvascular function showed a modest improvement in trial‐level data only. No consistent benefit was observed in subgroup analyses or between different vitamin D analogues.Conclusions: Vitamin D supplementation had no significant effect on most markers of vascular function in this analysis. Beveridge LA Beveridge, LA Author Khan F Khan, F Author 0000-0002-9889-0229 Struthers AD Struthers, AD Author
- Subjects :
- Paricalcitol
Male
Treatment outcome
Physiology
vitamin D
030204 cardiovascular system & hematology
0302 clinical medicine
endothelial function
systematic review
Cardiovascular Disease
Medicine
030212 general & internal medicine
vitamin D vascular function therapy
Young adult
Vitamin D
Vascular Stiffness/drug effects
Cardiovascular Diseases/diagnosis
Systematic Review and Meta‐Analysis
Middle Aged
3. Good health
Treatment Outcome
Cardiovascular Diseases
Meta-analysis
paricalcitol
Female
Cardiology and Cardiovascular Medicine
Vascular function
medicine.drug
Adult
Endothelium, Vascular/drug effects
Adolescent
vascular function
03 medical and health sciences
Young Adult
Vascular Stiffness
Vitamin D and neurology
Humans
Vitamin D/adverse effects
Aged
Vitamin d supplementation
business.industry
Hemodynamics
Vitamin D Deficiency
Increased risk
Hemodynamics/drug effects
Endothelial Function
Vitamin D Deficiency/diagnosis
Dietary Supplements
Systematic review
Endothelium, Vascular
Dietary Supplements/adverse effects
business
Biomarkers/blood
Biomarkers
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Beveridge, L A, Khan, F, Struthers, A D, Armitage, J, Barchetta, I, Bressendorff, I, Cavallo, M G, Clarke, R, Dalan, R, Dreyer, G, Gepner, A D, Forouhi, N G, Harris, R A, Hitman, G A, Larsen, T, Khadgawat, R, Marckmann, P, Mose, F H, Pilz, S, Scholze, A, Shargorodsky, M, Sokol, S I, Stricker, H, Zoccali, C & Witham, M D 2018, ' Effect of Vitamin D Supplementation on Markers of Vascular Function : A Systematic Review and Individual Participant Meta-Analysis ', Journal of the American Heart Association, vol. 7, no. 11, e008273 . https://doi.org/10.1161/JAHA.117.008273, Beveridge, L A, Khan, F, Struthers, A D, Armitage, J, Barchetta, I, Bressendorff, I, Cavallo, M G, Clarke, R, Dalan, R, Dreyer, G, Gepner, A D, Forouhi, N G, Harris, R A, Hitman, G A, Larsen, T, Khadgawat, R, Marckmann, P, Mose, F H, Pilz, S, Scholze, A, Shargorodsky, M, Sokol, S I, Stricker, H, Zoccali, C & Witham, M D 2018, ' Effect of vitamin D supplementation on markers of vascular function : A systematic review and individual participant meta-analysis ', Journal of the American Heart Association, vol. 7, no. 11, e008273 . https://doi.org/10.1161/JAHA.117.008273
- Accession number :
- edsair.doi.dedup.....5bd27fa41534bb7fd739bd5ae3be116c