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Retinoid receptors in human lung cancer and breast cancer
- Source :
- Mutation research. 350(1)
- Publication Year :
- 1996
-
Abstract
- Retinoids, the natural and synthetic vitamin A derivatives, are known to inhibit the proliferation of lung cancer and breast cancer cells and the growth of carcinogen-induced bronchogenic squamous cell carcinoma and mammary tumors, and have been used as chemoprevention agents against both types of cancer. However, clinical trials of retinoids in patients with advanced lung cancer and breast cancer have not been successful. In studying how retinoid sensitivity is lost in cancer cells, we have found that lack of the retinoic acid receptor beta (RAR beta) gene expression and its abnormal regulation by retinoic acid (RA) are common features in human lung cancer and breast cancer cells. The absence and abnormal RA regulation of RAR beta correlates with the loss of anti-proliferation effect of RA in hormone-independent breast cancer cells, and is due to different abnormalities found in cancer cells. Furthermore, expression of RAR beta gene in hormone-independent breast cancer cells restores their RA sensitivity. These data demonstrate that RAR beta can mediate the growth inhibitory effect of RA and suggest that the lack of RAR beta may contribute to retinoid resistance in certain cancer cells.
- Subjects :
- Lung Neoplasms
medicine.drug_class
Receptors, Retinoic Acid
Health, Toxicology and Mutagenesis
Retinoic acid receptor beta
Breast Neoplasms
Tretinoin
Biology
medicine.disease_cause
Breast cancer
Cancer stem cell
Genetics
medicine
Tumor Cells, Cultured
Humans
Retinoid
Lung cancer
Molecular Biology
Cancer
Cell Differentiation
medicine.disease
Gene Expression Regulation, Neoplastic
Retinoid X Receptors
Cancer cell
Mutation
Cancer research
Carcinogenesis
Cell Division
Transcription Factors
Subjects
Details
- ISSN :
- 00275107
- Volume :
- 350
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Mutation research
- Accession number :
- edsair.doi.dedup.....5bcf3ac40b026919d969dd10cbfddcb2