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Metaplastic Variant of Invasive Micropapillary Breast Carcinoma

Metaplastic Variant of Invasive Micropapillary Breast Carcinoma

Authors :
Gitika Aggarwal
Suash Sharma
Michelle D. Reid
Source :
International Journal of Surgical Pathology. 20:488-493
Publication Year :
2012
Publisher :
SAGE Publications, 2012.

Abstract

Invasive micropapillary carcinomas (IMC) and metaplastic breast carcinoma (MBC) have different clinicopathologic features. This study reports an unusual case of multifocal grade III IMC associated with MBC component in a 35-year-old woman. MBC was vimentin positive, pancytokeratin negative, and showed focal p63 positivity. Immunostains for estrogen and progesterone receptor, and fluorescence in situ hybridization for Her2/neu amplification were negative. All the left axillary lymph nodes dissected were positive for metastatic carcinoma with ductal and IMC patterns, but without metaplastic component. Postmastectomy computed tomography and magnetic resonance imaging scans showed metastases to lungs, liver, brain, and vertebrae. The biologic behavior of tumor was in accordance with histology, so that the nodal and distant metastases were testament to the underlying inherently aggressive IMC, whereas large tumor size and triple negativity reflected the features of MBC. To the best of the authors’ knowledge, this is the first report of a metaplastic variant of invasive micropapillary breast carcinoma with triple negative phenotype.

Details

ISSN :
19402465 and 10668969
Volume :
20
Database :
OpenAIRE
Journal :
International Journal of Surgical Pathology
Accession number :
edsair.doi.dedup.....5bcb855f83a04c3f4cf43ffb416283c0
Full Text :
https://doi.org/10.1177/1066896912436552