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Metaplastic Variant of Invasive Micropapillary Breast Carcinoma
Metaplastic Variant of Invasive Micropapillary Breast Carcinoma
- Source :
- International Journal of Surgical Pathology. 20:488-493
- Publication Year :
- 2012
- Publisher :
- SAGE Publications, 2012.
-
Abstract
- Invasive micropapillary carcinomas (IMC) and metaplastic breast carcinoma (MBC) have different clinicopathologic features. This study reports an unusual case of multifocal grade III IMC associated with MBC component in a 35-year-old woman. MBC was vimentin positive, pancytokeratin negative, and showed focal p63 positivity. Immunostains for estrogen and progesterone receptor, and fluorescence in situ hybridization for Her2/neu amplification were negative. All the left axillary lymph nodes dissected were positive for metastatic carcinoma with ductal and IMC patterns, but without metaplastic component. Postmastectomy computed tomography and magnetic resonance imaging scans showed metastases to lungs, liver, brain, and vertebrae. The biologic behavior of tumor was in accordance with histology, so that the nodal and distant metastases were testament to the underlying inherently aggressive IMC, whereas large tumor size and triple negativity reflected the features of MBC. To the best of the authors’ knowledge, this is the first report of a metaplastic variant of invasive micropapillary breast carcinoma with triple negative phenotype.
- Subjects :
- Adult
Pathology
medicine.medical_specialty
Axillary lymph nodes
Receptor, ErbB-2
Breast Neoplasms
Vimentin
Pathology and Forensic Medicine
Metastatic carcinoma
Neoplasms, Multiple Primary
Metaplasia
Biomarkers, Tumor
medicine
Carcinoma
Humans
Neoplasm Invasiveness
skin and connective tissue diseases
In Situ Hybridization, Fluorescence
Mastectomy
Neoplasm Staging
biology
business.industry
Carcinoma, Ductal, Breast
DNA, Neoplasm
Metaplastic Breast Carcinoma
medicine.disease
Combined Modality Therapy
Adenocarcinoma, Papillary
medicine.anatomical_structure
Receptors, Estrogen
Axilla
biology.protein
Adenocarcinoma
Female
Surgery
Lymph Nodes
Anatomy
medicine.symptom
Receptors, Progesterone
business
Invasive Micropapillary Breast Carcinoma
Subjects
Details
- ISSN :
- 19402465 and 10668969
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- International Journal of Surgical Pathology
- Accession number :
- edsair.doi.dedup.....5bcb855f83a04c3f4cf43ffb416283c0
- Full Text :
- https://doi.org/10.1177/1066896912436552