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Fixed-pressure nCPAP in patients with obstructive sleep apnea (OSA) syndrome and chronic obstructive pulmonary disease (COPD): a 24-month follow-up study
- Source :
- Sleepbreathing = SchlafAtmung. 14(2)
- Publication Year :
- 2009
-
Abstract
- The aim of this study was to investigate the time course of body weight, daytime sleepiness, and functional cardiorespiratory parameters in patients with both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea syndrome (OSA), after institution of domiciliary nasal continuous positive airway pressure (nCPAP).Twelve consecutive obese outpatients (mean age = 61 +/- 11 years; four women) were evaluated before (baseline) and after 3, 12, and 24 months of nocturnal nCPAP (4 h per night).At baseline, all patients were hypercapnic and hypoxemic, suffering from night desaturation (T (90) is the percentage of total recording time (TRT) spent with SaO(2)or= 90% = 38 +/- 2%) and sleepy (Epworth sleepiness scale [ESS] = 16.58 +/- 0.86). Three months after the implementation of nCPAP, daytime PaCO(2) and PaO(2) improved up to 45.1 +/- 0.9 and 69.0 +/- 1 mmHg, respectively; mean pulmonary artery pressure (MPAP) decreased from 24.7 +/- 1.1 to 19.2 +/- 04 mmHg. All other variables showed progressive improvements up to 12 months. At 3 and 12 months, mean body mass index was slightly decreased (to 31.6 +/- 0.2 and 30.7 +/- 0.1 kg/m(2), respectively); daytime sleepiness, nocturnal O(2) desaturation, and maximal inspiratory pressure were also improved and thereafter remained stable.In conclusion, in our patients with both severe OSA and mild-to-moderate COPD, arterial blood gasses and MPAP improved and stabilized after 3 months of nCPAP therapy, with the greatest improvements being in ESS score, T (90), and maximal inspiratory force from 3 up to 12 months; these parameters remained stable over the following 12 months. Finally, our data support early treatment with nCPAP in such patients.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Polysomnography
Positive pressure
Comorbidity
Disorders of Excessive Somnolence
Statistics, Nonparametric
Body Mass Index
Pulmonary Disease, Chronic Obstructive
COPD(chronic obstructive pulmonary disease)
Internal medicine
medicine
Humans
Continuous positive airway pressure
Obesity
Aged
Sleep disorder
COPD
Sleep Apnea, Obstructive
OSA (obstructive sleep apnea–hypopnea syndrome)
Continuous Positive Airway Pressure
business.industry
Respiratory disease
Body Weight
Sleep apnea
Carbon Dioxide
Middle Aged
medicine.disease
respiratory tract diseases
Obstructive sleep apnea
Oxygen
Otorhinolaryngology
nCPAP (nasal continuous positive airway pressure)
Anesthesia
Cardiology
Female
Neurology (clinical)
business
Lung Volume Measurements
Overlap syndrome (OSA + COPD)
Follow-Up Studies
Subjects
Details
- ISSN :
- 15221709
- Volume :
- 14
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Sleepbreathing = SchlafAtmung
- Accession number :
- edsair.doi.dedup.....5bc26b3d896df28971331e953e8c8e26