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The <scp>IL</scp> ‐13– <scp>OVOL</scp> 1– <scp>FLG</scp> axis in atopic dermatitis
- Source :
- Immunology
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Despite sharing interleukin‐4 receptor α (IL‐4Rα) in their signaling cascades, IL‐4 and IL‐13 have different functions in atopic inflammation. IL‐13 preferentially participates in the peripheral tissues because tissue‐resident group 2 innate lymphoid cells produce IL‐13 but not IL‐4. In contrast, lymph node T follicular helper cells express IL‐4 but not IL‐13 to regulate B‐cell immunity. The dominant microenvironment of IL‐13 is evident in the lesional skin of atopic dermatitis (AD). The IL‐13‐rich local milieu causes barrier dysfunction by down‐regulating the OVOL1–filaggrin (FLG) axis and up‐regulating the periostin–IL‐24 axis. Genome‐wide association studies also point to the crucial involvement of the IL‐13, OVOL1 and FLG genes in the pathogenesis of AD. Biologics targeting IL‐13, such as the anti‐IL‐4Rα antibody dupilumab and the anti‐IL‐13 antibody tralokinumab, successfully improve AD lesions and further highlight the importance of IL‐13 in the pathogenesis of AD.
- Subjects :
- 0301 basic medicine
Immunology
Inflammation
Filaggrin Proteins
Antibodies, Monoclonal, Humanized
Dermatitis, Atopic
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Intermediate Filament Proteins
medicine
Animals
Humans
Immunology and Allergy
Lymphocytes
Review Articles
Skin
Interleukin-13
business.industry
Innate lymphoid cell
Antibodies, Monoclonal
Interleukin-4 Receptor alpha Subunit
Atopic dermatitis
medicine.disease
Dupilumab
Immunity, Innate
Biological Therapy
DNA-Binding Proteins
030104 developmental biology
Interleukin 13
medicine.symptom
business
Signal Transduction
Transcription Factors
030215 immunology
Tralokinumab
Filaggrin
Subjects
Details
- ISSN :
- 13652567 and 00192805
- Volume :
- 158
- Database :
- OpenAIRE
- Journal :
- Immunology
- Accession number :
- edsair.doi.dedup.....5bbbe04a90534863febbd4a3458a2258