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The slow releasing hydrogen sulfide donor GYY4137 reduces neointima formation upon FeCl3 injury of the carotid artery in mice
- Source :
- Clinical Hemorheology and Microcirculation. 75:409-417
- Publication Year :
- 2020
- Publisher :
- IOS Press, 2020.
-
Abstract
- INTRODUCTION: Neointima formation is closely linked to vascular stenosis and occurs after endothelial damage. Hydrogen sulfide is an endogenous pleiotropic mediator with numerous positive effects on the cardio vascular system. OBJECTIVE: This study evaluates the effect of the slow releasing hydrogen sulfide donor GYY4137 (GYY) on neointimal formation in vivo. METHODS: The effect of GYY on neointimal formation in the carotid artery was studied in the FeCl3 injury model in GYY- or vehicle-treated mice. The carotid arteries were studied at days 7 and 21 after treatment by means of histology and immunohistochemistry for proliferating cell nuclear antigen (PCNA) and alpha smooth muscle actin (α-SMA). RESULTS: GYY treatment significantly reduced the maximal diameter and the area of the newly formed neointima on both days 7 and 21 when compared to vehicle treatment. GYY additionally reduced the number of PCNA- and α-SMA-positive cells within the neointima on day 21 after FeCl3 injury of the carotid artery. CONCLUSIONS: Summarizing, single treatment with the slow releasing hydrogen sulfide donor GYY reduced the extent of the newly formed neointima by affecting the cellular proliferation at the site of vascular injury.
- Subjects :
- Male
0301 basic medicine
Neointima
medicine.medical_specialty
Carotid Artery, Common
Physiology
Morpholines
Endogeny
030204 cardiovascular system & hematology
Mice
03 medical and health sciences
0302 clinical medicine
In vivo
Physiology (medical)
Internal medicine
medicine
Animals
Hydrogen Sulfide
biology
Vascular disease
Chemistry
Arterial stenosis
Organothiophosphorus Compounds
Hematology
medicine.disease
Proliferating cell nuclear antigen
Disease Models, Animal
Carotid Arteries
030104 developmental biology
Endocrinology
Circulatory system
cardiovascular system
biology.protein
Cardiology and Cardiovascular Medicine
Vascular Stenosis
Subjects
Details
- ISSN :
- 18758622 and 13860291
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Clinical Hemorheology and Microcirculation
- Accession number :
- edsair.doi.dedup.....5baf3d7953b30be89b72614f5b4ad0fe