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The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013
- Source :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 21(5)
- Publication Year :
- 2014
-
Abstract
- Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study. Urethral discharge was collected from male patients with urethritis at 26 medical facilities from March 2012 to January 2013. Of the 151 specimens, 103 N. gonorrhoeae strains were tested for susceptibility to 20 antimicrobial agents. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) 90% of ceftriaxone increased to 0.125 μg/ml, and 11 (10.7%) strains were considered less susceptible with an MIC of 0.125 μg/ml. There were 11 strains resistant to cefixime, and the MICs of these strains were 0.5 μg/ml. The distributions of the MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin, were bimodal. Sitafloxacin, a fluoroquinolone, showed strong activity against all strains, including strains resistant to other three fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin. The azithromycin MICs in 2 strains were 1 μg/ml.
- Subjects :
- Microbiology (medical)
Sitafloxacin
Adult
Male
Adolescent
Microbial Sensitivity Tests
Penicillins
Azithromycin
medicine.disease_cause
Microbiology
Tosufloxacin
Young Adult
Japan
Levofloxacin
Cefixime
Drug Resistance, Bacterial
medicine
Humans
Pharmacology (medical)
Urethritis
Aged
business.industry
Ceftriaxone
Middle Aged
Antimicrobial
medicine.disease
Neisseria gonorrhoeae
Anti-Bacterial Agents
Ciprofloxacin
Infectious Diseases
Population Surveillance
business
medicine.drug
Fluoroquinolones
Subjects
Details
- ISSN :
- 14377780
- Volume :
- 21
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
- Accession number :
- edsair.doi.dedup.....5ba908c09e14d730c4830d359468fb38