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The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells
- Source :
- Toxins; Volume 9; Issue 11; Pages: 346, Toxins, Vol 9, Iss 11, p 346 (2017), Toxins
- Publication Year :
- 2017
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2017.
-
Abstract
- Spider venoms constitute incredibly diverse libraries of compounds, many of which are involved in prey capture and defence. Polyamines are often prevalent in the venom and target ionotropic glutamate receptors. Here we show that a novel spider polyamine, PA366, containing a hydroxyphenyl-based structure is present in the venom of several species of tarantula, and has selective toxicity against MCF-7 breast cancer cells. By contrast, a polyamine from an Australian funnel-web spider venom, which contains an identical polyamine tail to PA366 but an indole-based head-group, is only cytotoxic at high concentrations. Our results suggest that the ring structure plays a role in the cytotoxicity and that modification to the polyamine head group might lead to more potent and selective compounds with potential as novel cancer treatments.
- Subjects :
- 0301 basic medicine
Magnetic Resonance Spectroscopy
Spider Venoms
Cell Survival
Health, Toxicology and Mutagenesis
lcsh:Medicine
Venom
Biology
Toxicology
complex mixtures
Article
03 medical and health sciences
chemistry.chemical_compound
NMR spectroscopy
polyamine
Cell Line, Tumor
Polyamines
Animals
Humans
cancer
spider venom
cytotoxicity
Cytotoxicity
lcsh:R
Spiders
Spider toxin
3. Good health
030104 developmental biology
chemistry
Biochemistry
Toxicity
Cancer cell
Female
Polyamine
Ionotropic effect
Subjects
Details
- Language :
- English
- ISSN :
- 20726651
- Database :
- OpenAIRE
- Journal :
- Toxins; Volume 9; Issue 11; Pages: 346
- Accession number :
- edsair.doi.dedup.....5b9e988d8425d6cf69fcd1203bc6cade
- Full Text :
- https://doi.org/10.3390/toxins9110346