Back to Search
Start Over
Inhibition of cholinergic interneurons potentiates corticostriatal transmission in D1 receptor-expressing medium-sized spiny neurons and restores motor learning in parkinsonian condition
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- SUMMARYStriatal cholinergic interneurons (CINs) respond to salient or reward prediction-related stimuli after conditioning with brief pauses in their activity, implicating them in learning and action selection. This pause is lost in animal models of Parkinson’s disease. How this signal regulates the functioning of the striatum remains an open question. To address this issue, we examined the impact of CIN firing inhibition on glutamatergic transmission between the cortex and the medium-sized spiny projection neurons expressing dopamine D1 receptors (D1 MSNs). Brief interruption of CIN activity had no effect in control condition whereas it increased glutamatergic responses in D1 MSNs after nigrostriatal dopamine denervation. This potentiation was dependent upon M4 muscarinic receptor and protein kinase A. Decreasing CIN firing by opto/chemogenetic strategies in vivo rescued long-term potentiation in some MSNs and alleviated motor learning deficits in parkinsonian mice. Taken together, our findings demonstrate that the control exerted by CINs on corticostriatal transmission and striatal-dependent motor-skill learning depends on the integrity of dopaminergic inputs.
- Subjects :
- 0303 health sciences
Summary: 161
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Dopaminergic
Discussion: 1 644
Long-term potentiation
Striatum
Biology
Medium spiny neuron
03 medical and health sciences
Glutamatergic
0302 clinical medicine
Dopamine receptor D1
nervous system
Dopamine
Introduction: 714
medicine
Cholinergic
Title: 20
Results: 1 844
Neuroscience
030217 neurology & neurosurgery
030304 developmental biology
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....5b95cd0574cfe401be15991c92b9cd2a