Back to Search
Start Over
Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish
- Source :
- International Journal of Molecular Sciences, Volume 21, Issue 9, International Journal of Molecular Sciences, Vol 21, Iss 3127, p 3127 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Relapse of acute lymphoblastic leukemia (ALL) is dangerous and it worsens the prognosis of patients<br />however, prognostic markers or therapeutic targets for ALL remain unknown. In the present study, using databases such as TARGET, GSE60926 and GSE28460, we determined that KIF2C and its binding partner, KIF18B are overexpressed in patients with relapsed ALL compared to that in patients diagnosed with ALL for the first time. As 50% of the residues are exactly the same and the signature domain of KIF2C is highly conserved between human and zebrafish, we used zebrafish embryos as a model to investigate the function of kif2c in vivo. We determined that kif2c is necessary for lymphopoiesis in zebrafish embryos. Additionally, we observed that kif2c is not related to differentiation of HSCs<br />however, it is important for the maintenance of HSCs as it provides survival signals to HSCs. These results imply that the ALL relapse-related gene KIF2C is linked to the survival of HSCs. In conclusion, we suggest that KIF2C can serve as a novel therapeutic target for relapsed ALL.
- Subjects :
- education
Embryonic hematopoiesis
Catalysis
lcsh:Chemistry
Inorganic Chemistry
In vivo
hemic and lymphatic diseases
In patient
Lymphopoiesis
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Gene
Zebrafish
Spectroscopy
KIF2C
biology
Organic Chemistry
hemic and immune systems
General Medicine
GEO
zebrafish
biology.organism_classification
hematopoiesis
Computer Science Applications
Haematopoiesis
TARGET
lcsh:Biology (General)
lcsh:QD1-999
Cancer research
ALL
Function (biology)
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....5b8cc7fe0c9a94a729f97c396fce4fda