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Widespread insecticide resistance in Aedes aegypti L. from New Mexico, U.S.A
- Source :
- PLoS ONE, Vol 14, Iss 2, p e0212693 (2019), PLoS ONE
- Publication Year :
- 2019
- Publisher :
- Public Library of Science (PLoS), 2019.
-
Abstract
- BackgroundAedes aegypti mosquitoes are vectors of a variety of emerging viral pathogens, including yellow fever, dengue, chikungunya, and Zika virus. This species has established endemic populations in all cities across southern New Mexico sampled to date. Presently, control of Aedes-borne viruses relies on deployment of insecticides to suppress mosquito populations, but the evolution of insecticide resistance threatens the success of vector control programs. While insecticide resistance is quite common in Ae. aegypti field populations across much of the U.S., the resistance status of this species in populations from New Mexico has not previously been assessed.ResultsFirst, we collected information on pesticide use in cities in southern New Mexico and found that the most commonly used active ingredients were pyrethroids. The use of insecticides with the same mode-of-action over multiple years is likely to promote the evolution of resistance. To determine if there was evidence of resistance in some cities in southern New Mexico, we collected Ae. aegypti from the same cities and established laboratory strains to assess resistance to pyrethroid insecticides and, for a subset of populations, to organophosphate insecticides. F2 or F4 generation mosquitoes were assessed for insecticide resistance using bottle test bioassays. The majority of the populations from New Mexico that we analyzed were resistant to the pyrethroids permethrin and deltamethrin. A notable exception to this trend were mosquitoes from Alamogordo, a city that did not report using pyrethroid insecticides for vector control. We screened individuals from each population for known knock down resistance (kdr) mutations via PCR and found a strong association between the presences of the F1534C kdr mutation in the para gene of Ae. aegypti (homologue to F1534C in Musca domestica L.) and pyrethroid resistance.ConclusionHigh-level pyrethroid resistance is common in Ae. aegypti from New Mexico and geographic variation in such resistance is likely associated with variation in usage of pyrethroids for vector control. Resistance monitoring and management is recommended in light of the potential for arbovirus outbreaks in this state. Also, alternative approaches to mosquito control that do not involve insecticides should be explored.
- Subjects :
- Insecticides
Veterinary medicine
New Mexico
Drug Resistance
Disease Vectors
medicine.disease_cause
Mosquitoes
Geographical locations
chemistry.chemical_compound
0302 clinical medicine
Aedes
Pyrethrins
Medicine and Health Sciences
Chikungunya
0303 health sciences
education.field_of_study
Multidisciplinary
Pyrethroid
Eukaryota
Agriculture
Insects
Mosquito control
Infectious Diseases
Medicine
Agrochemicals
Research Article
medicine.drug
Arthropoda
Infectious Disease Control
Science
030231 tropical medicine
Population
Mosquito Vectors
Aedes aegypti
Aedes Aegypti
Biology
Arbovirus
03 medical and health sciences
parasitic diseases
Genetics
medicine
Animals
Point Mutation
Pesticides
education
030304 developmental biology
Organisms
Biology and Life Sciences
biology.organism_classification
medicine.disease
Invertebrates
United States
Insect Vectors
Species Interactions
Deltamethrin
chemistry
North America
Mutation
Pest Control
People and places
Permethrin
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....5b823f5da942721ce7c2a36d837bede4