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Quercetin Improves Baroreflex Sensitivity in Spontaneously Hypertensive Rats
- Source :
- Molecules; Volume 17; Issue 11; Pages: 12997-13008, Molecules, Vol 17, Iss 11, Pp 12997-13008 (2012), Molecules
- Publication Year :
- 2012
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2012.
-
Abstract
- Quercetin is a well-known antioxidant. Here, we investigated the effects of treatment with quercetin on mean arterial pressure (MAP), heart rate (HR) and baroreflex sensitivity (BRS) in spontaneously hypertensive rats (SHR). SHR and their controls (WKY) were orally treated with quercetin (2, 10 or 25 mg/kg/day) or saline for seven days. On the 8th day, MAP and HR were recorded. BRS was tested using phenylephrine (8 mg/kg, i.v.) and sodium nitroprusside (25 mg/kg, i.v.). Oxidative stress was measured by tiobarbituric acid reactive species assay. The doses of 10 (n = 8) and 25 mg/kg (n = 8) were able to decrease the MAP in SHR (n = 9) (163 ± 4 and 156 ± 5 vs. 173 ± 6, respectively, p < 0.05) but not in WKY (117 ± 1 and 118 ± 2 vs. 113 ± 1, respectively, p < 0.05). The dose of 25 mg/kg/day increased the sensitivity of parasympathetic component of the baroreflex (−2.47 ± 0.31 vs. −1.25 ± 0.8 bpm/mmHg) and decreased serum oxidative stress in SHR (2.04 ± 0.17 vs. 3.22 ± 0.37 nmol/mL, n = 6). Our data suggest that treatment with quercetin reduces hypertension and improves BRS in SHR via reduction in oxidative stress.
- Subjects :
- Male
medicine.medical_specialty
Mean arterial pressure
Sympathetic Nervous System
antioxidant
hypertension
medicine.medical_treatment
Pharmaceutical Science
Blood Pressure
Baroreflex
medicine.disease_cause
Kidney
Rats, Inbred WKY
Thiobarbituric Acid Reactive Substances
Article
Antioxidants
Analytical Chemistry
quercetin
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
Parasympathetic Nervous System
Internal medicine
Rats, Inbred SHR
Drug Discovery
Heart rate
medicine
Animals
baroreflex
Physical and Theoretical Chemistry
Phenylephrine
Saline
Antihypertensive Agents
Chemistry
Myocardium
Organic Chemistry
Rats
Oxidative Stress
Endocrinology
Liver
Chemistry (miscellaneous)
Molecular Medicine
Sodium nitroprusside
Lipid Peroxidation
Quercetin
Oxidative stress
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Database :
- OpenAIRE
- Journal :
- Molecules; Volume 17; Issue 11; Pages: 12997-13008
- Accession number :
- edsair.doi.dedup.....5b7f350f3e7db22dabd7f4a1e33d3d0d
- Full Text :
- https://doi.org/10.3390/molecules171112997