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Pilot study of combination therapy with transcatheter arterial infusion chemotherapy using iodized oil and percutaneous radiofrequency ablation during occlusion of hepatic blood flow for hepatocellular carcinoma
- Source :
- American journal of clinical oncology. 31(4)
- Publication Year :
- 2008
-
Abstract
- OBJECTIVE We have reported that radiofrequency (RF) ablation with balloon occlusion of the hepatic artery (balloon-occluded RF ablation) increases the coagulation area compared with standard RF ablation. In this study, we evaluated the efficacy and safety of combination therapy with transcatheter arterial infusion chemotherapy (TAI) using iodized oil and balloon-occluded RF ablation in patients with hepatocellular carcinoma. PATIENTS AND METHODS We studied 12 patients with 12 HCC nodules (mean tumor diameter, 27.3 mm). All patients were classified as Child-Pugh Class A. Immediately after TAI using iodized oil, we performed balloon-occluded RF ablation. RESULTS One treatment session of the combination therapy was done for 10 of 12 nodules (83%). The greatest long-axis and short-axis dimensions of the area coagulated after the combination therapy were 48.8+/- 5.5 mm and 41.9 +/- 4.1 mm, respectively. During follow-up (mean, 33.4 months), there was no local recurrence. The 1, 2, and 3-year survival rates were 100%, 92%, and 83%, respectively. No fatal complications were observed. CONCLUSIONS The combination therapy is an effective and safe treatment under favorable liver reserve capacity. Using the combination therapy, it is possible to finish one treatment session for patients with HCC nodules measuring less than 3 cm in greatest dimension.
- Subjects :
- Male
Cancer Research
medicine.medical_specialty
Percutaneous
Carcinoma, Hepatocellular
Combination therapy
Radiofrequency ablation
medicine.medical_treatment
Mitomycin
Pilot Projects
law.invention
Hepatic Artery
law
Occlusion
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Infusions, Intra-Arterial
Prospective Studies
Chemoembolization, Therapeutic
Aged
Epirubicin
Chemotherapy
business.industry
Liver Neoplasms
Iodized Oil
Balloon Occlusion
Middle Aged
medicine.disease
Ablation
Combined Modality Therapy
Survival Rate
medicine.anatomical_structure
Treatment Outcome
Oncology
Hepatocellular carcinoma
Catheter Ablation
Female
Radiology
business
Tomography, X-Ray Computed
Artery
Follow-Up Studies
Subjects
Details
- ISSN :
- 1537453X
- Volume :
- 31
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- American journal of clinical oncology
- Accession number :
- edsair.doi.dedup.....5b7e399a97d82e7ebcad687c285bf3e7