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Omega-3 Fatty Acids and Their Role in Pediatric Cancer
- Source :
- Nutrients, Vol 13, Iss 1800, p 1800 (2021), Nutrients
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Background: Malnutrition is common in children with cancer and is associated with adverse clinical outcomes. The need for supportive care is becoming ever more evident and the role of nutrition in oncology is still not sufficiently understood. In particular, the consequences of macro- and micronutrient deficiencies require further research. As epidemiological data suggest anti-tumoral properties of omega-3 (n-3) polyunsaturated fatty acids (PUFAs), we reviewed the role of nutrition and n-3 supplementation in pediatric oncology. Methods: A comprehensive literature search was conducted on PubMed through 5 February 2021 to select meta-analyses, systematic reviews, observational studies, and individual randomized controlled trials (RCTs) on macro- and micronutrient supplementation in pediatric oncology. The search strategy included the following medical subject headings (MeSH) and keywords: “childhood cancer”, “pediatric oncology”, “nutritional status”, “malnutrition”, and “omega-3-fatty-acids”. The reference lists of all relevant articles were screened to include potentially pertinent studies. Results: We summarize evidence about the importance of adequate nutrition in childhood cancer and the role of n-3 PUFAs and critically interpret findings. Possible effects of supplementation on the nutritional status and benefits during chemotherapy are discussed as well as strategies for primary and secondary prevention. Conclusion: We here describe the obvious benefits of omega-3 supplementation in childhood cancer. Further large scale clinical trials are required to verify potential anti-cancer effects of n-3 fatty acids.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Databases, Factual
Nutritional Status
Review
law.invention
03 medical and health sciences
0302 clinical medicine
Cancer Survivors
Drug Therapy
Randomized controlled trial
children
prevention
law
Fatty Acids, Omega-6
Neoplasms
Fatty Acids, Omega-3
Prevalence
Humans
Medicine
TX341-641
Child
Intensive care medicine
chemistry.chemical_classification
Nutrition and Dietetics
omega-3 fatty acids
business.industry
Nutrition. Foods and food supply
Malnutrition
Cancer
medicine.disease
Pediatric cancer
Clinical trial
030104 developmental biology
Systematic review
nutrition
chemistry
030220 oncology & carcinogenesis
Dietary Supplements
oncology
supplementation
Cytokines
Observational study
business
Food Science
Polyunsaturated fatty acid
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 1800
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....5b7ce2cf94ed03db46520733c9ae2274