Back to Search
Start Over
The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in Vitamin D-Deficient Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
- Source :
- Hormone and Metabolic Research. 48:446-451
- Publication Year :
- 2016
- Publisher :
- Georg Thieme Verlag KG, 2016.
-
Abstract
- The current study was conducted to assess the effects of vitamin D-K-calcium co-supplementation on endocrine, inflammation, and oxidative stress biomarkers in vitamin D-deficient women with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was performed on 60 vitamin D-deficient women diagnosed with PCOS aged 18–40 years old. Participants were randomly allocated into 2 groups to intake either 200 IU vitamin D, 90 μg vitamin K plus, 500 mg calcium supplements (n=30), or placebo (n=30) twice a day for 8 weeks. Endocrine, inflammation, and oxidative stress biomarkers were quantified at the beginning and the end of the study. After 8 weeks of intervention, compared with the placebo, vitamin D-K-calcium co-supplementation resulted in a significant reduction in serum-free testosterone (− 2.1±1.6 vs.+0.1±1.0 pg/ml, p
- Subjects :
- Adult
0301 basic medicine
Vitamin
medicine.medical_specialty
Vitamin K
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Placebo-controlled study
Endocrine System
030209 endocrinology & metabolism
Placebo
medicine.disease_cause
Biochemistry
vitamin D deficiency
Placebos
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Double-Blind Method
Internal medicine
Vitamin D and neurology
medicine
Humans
Endocrine system
Vitamin D
Inflammation
business.industry
Biochemistry (medical)
General Medicine
Vitamin D Deficiency
medicine.disease
Polycystic ovary
Oxidative Stress
030104 developmental biology
chemistry
Dietary Supplements
Calcium
Female
business
Biomarkers
Oxidative stress
Polycystic Ovary Syndrome
Subjects
Details
- ISSN :
- 14394286 and 00185043
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Hormone and Metabolic Research
- Accession number :
- edsair.doi.dedup.....5b7af24a8c98ec4511e8d0f68d74e934