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Associations of Sleep Characteristics with Cerebrospinal Fluid sTREM2 in Cognitively Normal Older Adults: the CABLE Study
- Source :
- Neurotoxicity research. 39(4)
- Publication Year :
- 2020
-
Abstract
- As brain insults, sleep disorders could enhance microglial activation and aggravate neuroinflammation. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) serves as a readout for TREM2-associated microglial responses. We aimed to study the association of sleep characteristics with CSF sTREM2 in cognitively normal (CN) older adults. Linear and non-linear regression analyses were conducted in 830 participants with measurements of sleep characteristics and CSF sTREM2, after adjusting for age, sex, education, the Chinese-Modified Mini-Mental State Examination (CM-MMSE) scores, and APOE4 status. These analyses were also performed in amyloid-negative (A −) and amyloid-positive (A +) individuals. Linear relationships between sleep characteristics and CSF sTREM2 were found. In all the participants, sleep efficiency score in Pittsburgh Sleep Quality Index (PSQI) (p = 0.037) showed a positive linear association with CSF sTREM2. In A + individuals, the grade of PSQI total score (p = 0.011) as well as subjective sleep quality score (p = 0.048) and sleep efficiency score (p
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
China
Neurology
Toxicology
Bedtime
Pittsburgh Sleep Quality Index
03 medical and health sciences
0302 clinical medicine
Cerebrospinal fluid
Cognition
Alzheimer Disease
Internal medicine
medicine
Humans
Neurochemistry
Receptors, Immunologic
Life Style
Aged
Aged, 80 and over
Membrane Glycoproteins
business.industry
General Neuroscience
Middle Aged
Sleep in non-human animals
030104 developmental biology
Cross-Sectional Studies
Sleep Quality
Nocturnal sleep
Subjective sleep
Female
business
030217 neurology & neurosurgery
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 14763524
- Volume :
- 39
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Neurotoxicity research
- Accession number :
- edsair.doi.dedup.....5b6fe995af04f2159cc7ce5176d2ee1a