Back to Search
Start Over
Enhanced Responsiveness of the Coronary Blood Vessel of the Dog Heart-Lung Preparation to PGI2 after Chronic Chemical Sympathectomy
- Source :
- Japanese Journal of Pharmacology. 38:325-328
- Publication Year :
- 1985
- Publisher :
- Elsevier BV, 1985.
-
Abstract
- Chronic chemical denervation of the sympathetic nervous system with 6-OH dopamine resulted in an augmentation of the coronary blood flow (CBF) increase inherent in the canine heart-lung preparation, but not in an augmented accumulation of 6-keto PGF1α in the circulating blood. In denervated HLP, 6-keto PGF1α was lower and the vasodilator response to PGF2 larger at the start of the experiments. It was concluded that exaggerated increase in CBF was due to a potentiation of the vasodilator response to PGI2.
- Subjects :
- Male
medicine.medical_specialty
Coronary blood vessel
Sympathetic nervous system
Time Factors
Vasodilation
6-Ketoprostaglandin F1 alpha
Hydroxydopamines
Dogs
Dopamine
Internal medicine
medicine
Animals
Oxidopamine
Pharmacology
Lung
business.industry
Sympathectomy, Chemical
Heart
Long-term potentiation
Blood flow
Coronary Vessels
Epoprostenol
Endocrinology
medicine.anatomical_structure
cardiovascular system
Cardiology
Female
lipids (amino acids, peptides, and proteins)
business
circulatory and respiratory physiology
medicine.drug
Blood vessel
Subjects
Details
- ISSN :
- 00215198
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Japanese Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....5b6dd890b89e13c5da6e979c625e928f