Back to Search
Start Over
An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules
- Source :
- Repositório Institucional da UFMG, Universidade Federal de Minas Gerais (UFMG), instacron:UFMG, Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 2 (2017); e16064, Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 2 (2017); e16064, Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 2 (2017); e16064, Brazilian Journal of Pharmaceutical Sciences, Universidade de São Paulo (USP), instacron:USP, Brazilian Journal of Pharmaceutical Sciences, Vol 53, Iss 2 (2017), Brazilian Journal of Pharmaceutical Sciences, Volume: 53, Issue: 2, Article number: e16064, Published: 22 JUN 2017
- Publication Year :
- 2017
- Publisher :
- Universidade Federal de Minas Gerais, 2017.
-
Abstract
- Prednisone is an anti-inflammatory steroid drug widely used in clinical practice. However, no high-performance liquid chromatographic (HPLC) method has been described in the literature for the determination of prednisone in capsules until now. Thus, an HPLC method was developed using a C18 (250x4.0, 5 µm) column, with methanol:water (70:30) as mobile phase at a flow rate of 1 mL/min and detection at 240 nm. The developed method was validated following current Brazilian legislation. Additionally, linearity was assessed by evaluating the assumptions of normality, homoscedasticity, and independency of residuals, and the fit to the linear model. The method showed linearity (r2>0.99) over the range of 14.0-26.0 µg/mL, selectivity, precision (RSD
- Subjects :
- Chromatography
Chemistry
Content determination
High performance liquid chromatography/validation
Analytical chemistry
Linearity
lcsh:RS1-441
Capsules
02 engineering and technology
Química
High-performance liquid chromatography
Linearity assessment
Clinical Practice
lcsh:Pharmacy and materia medica
020210 optoelectronics & photonics
Prednisone
Prednisona
0202 electrical engineering, electronic engineering, information engineering
medicine
General Pharmacology, Toxicology and Pharmaceutics
Hplc method
Cápsulas (Farmácia)
medicine.drug
Subjects
Details
- Language :
- Portuguese
- ISSN :
- 21759790 and 19848250
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional da UFMG, Universidade Federal de Minas Gerais (UFMG), instacron:UFMG, Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 2 (2017); e16064, Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 2 (2017); e16064, Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 2 (2017); e16064, Brazilian Journal of Pharmaceutical Sciences, Universidade de São Paulo (USP), instacron:USP, Brazilian Journal of Pharmaceutical Sciences, Vol 53, Iss 2 (2017), Brazilian Journal of Pharmaceutical Sciences, Volume: 53, Issue: 2, Article number: e16064, Published: 22 JUN 2017
- Accession number :
- edsair.doi.dedup.....5b6bbb955498ec643ad9e5e1d60d1d0b