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5-Aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors
- Source :
- Bioorganicmedicinal chemistry letters. 22(5)
- Publication Year :
- 2011
-
Abstract
- 5-Aryl-4-carboxamide-1,3-oxazoles are a novel, potent and selective series of GSK-3 inhibitors. The optimization of the series to yield compounds with cell activity and brain permeability is described.
- Subjects :
- Models, Molecular
Bipolar Disorder
medicine.drug_class
Clinical Biochemistry
Pharmaceutical Science
Carboxamide
Biochemistry
Cell activity
chemistry.chemical_compound
Glycogen Synthase Kinase 3
Structure-Activity Relationship
GSK-3
Drug Discovery
medicine
Animals
Humans
Molecular Biology
Oxazoles
Protein Kinase Inhibitors
Chemistry
Aryl
Organic Chemistry
Brain
Combinatorial chemistry
Rats
Molecular Medicine
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 22
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....5b66eb76e81f7b2c32b4bb452fbb6ccb