Back to Search
Start Over
Combined effect of surface nano-topography and delivery of therapeutics on the adhesion of tumor cells on porous silicon substrates
- Source :
- Microelectronic Engineering. 158:6-10
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Porous silicon is a nano material in which pores with different sizes, densities and depths are infiltrated in conventional silicon imparting it augmented properties including biodegradability, biocompatibility, photoluminescence. Here, we realized porous silicon substrates in which the pore size and the fractal dimension were varied over a significant range. We loaded the described substrates with a PtCl(O,O'-acac)(DMSO) antitumor drug and determined its release profile as a function of pore size over time up to 15days. We observed that the efficacy of delivery augments with the pore size moving from small (~8nm, efficiency of delivery ~0.2) to large (~55nm, efficiency of delivery ~0.7). Then, we verified the adhesion of MCF-7 breast cancer cells on the described substrates with and without the administration of the antitumor drug. This permitted to decouple and understand the coincidental effects of nano-topography and a controlled dosage of drugs on cell adhesion and growth. While large pore sizes guarantee elevated drug dosages, large fractal dimensions boost cell adhesion on a surface. For the particular case of tumor cells and the delivery of an anti-tumor drug, substrates with a small fractal dimension and large pore size hamper cell growth. The competition between nano-topography and a controlled dosage of drugs may either accelerate or block the adhesion of cells on a nanostructured surface, for applications in tissue engineering, regenerative medicine, personalized lab-on-a-chips, and the rational design of implantable drug delivery systems. Display Omitted We realized porous silicon substrates with a varying pore size and fractal dimension.We loaded the substrates with an antitumor drug and determined its release profile over time.We verified the adhesion of MCF-7 cancer cells on the porous substrates.We decoupled the effects of nano-topography and drug delivery on cell adhesion.Large pore sizes boost drug release, large fractal dimensions accelerate cell adhesion.
- Subjects :
- 0301 basic medicine
Atomic and Molecular Physics, and Optic
Materials science
Biocompatibility
Silicon
Nano-topography
Surfaces, Coatings and Film
chemistry.chemical_element
Nanotechnology
Condensed Matter Physic
02 engineering and technology
Porous silicon
Nanomaterials
03 medical and health sciences
Tissue engineering
Electrical and Electronic Engineering
Cell adhesion
Electronic, Optical and Magnetic Material
technology, industry, and agriculture
Adhesion
021001 nanoscience & nanotechnology
Condensed Matter Physics
Anti-tumor drug
Atomic and Molecular Physics, and Optics
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
030104 developmental biology
chemistry
Drug delivery
0210 nano-technology
Subjects
Details
- ISSN :
- 01679317
- Volume :
- 158
- Database :
- OpenAIRE
- Journal :
- Microelectronic Engineering
- Accession number :
- edsair.doi.dedup.....5b622fa77a9fddb628a9c6f50b187d98