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Enantioselective Synthesis of Acyclic α-Quaternary Carboxylic Acid Derivatives through Iridium-Catalyzed Allylic Alkylation
- Source :
- Angewandte Chemie. 129:11703-11706
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- The first highly enantioselective iridium-catalyzed allylic alkylation that provides access to products bearing an allylic all-carbon quaternary stereogenic center has been developed. The reaction utilizes a masked acyl cyanide (MAC) reagent, which enables the one-pot preparation of α-quaternary carboxylic acids, esters, and amides with a high degree of enantioselectivity. The utility of these products is further explored through a series of diverse product transformations.
- Subjects :
- Allylic rearrangement
Alkylation
Carboxylic acid
Carboxylic Acids
Iridium
010402 general chemistry
01 natural sciences
Article
Catalysis
Umpolung
Stereocenter
Tsuji–Trost reaction
Organic chemistry
chemistry.chemical_classification
Molecular Structure
Chemistry
010405 organic chemistry
Enantioselective synthesis
food and beverages
Stereoisomerism
General Chemistry
General Medicine
0104 chemical sciences
Allyl Compounds
Reagent
Subjects
Details
- ISSN :
- 00448249
- Volume :
- 129
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie
- Accession number :
- edsair.doi.dedup.....5b622c1f1d0075eb1dee397df69e53f5