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Low-frequency EEG oscillations associated with information processing in schizophrenia
- Source :
- Schizophrenia Research. 115:222-230
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Numerous studies have described attenuated event-related potential (ERP) component amplitudes in schizophrenia (e.g., P300, Mismatch Negativity (MMN), Error Negativity/Error-Related Negativity (Ne/ERN)). Functional magnetic resonance imaging (fMRI) studies have typically shown decreased recruitment of diverse brain areas during performance of tasks that elicit the above ERP components. Recent research suggests that phase-resetting of slow-oscillations (e.g., in the delta and theta bands) underlies the potentials observed in ERP averages. Several studies have reported that slow-oscillations are increased in amplitude in people with schizophrenia at rest. Few studies have examined event-related low-frequency oscillations in schizophrenia. We examined event-related evoked and induced delta and theta activity in 17 people with schizophrenia and 17 healthy controls in two go/no-go task variants. We analyzed stimulus-related and response-related oscillations associated with correct-hits, correct-rejects and false-alarms. Our results reveal a pattern of reduced delta and theta activity for task-relevant events in schizophrenia. The findings indicate that while low-frequency oscillations are increased in amplitude at rest, they are not coordinated effectively in schizophrenia during various information processing tasks including target-detection, response-inhibition and error-detection. This slow-oscillation coordination abnormality may help explain the decreased recruitment of brain areas seen in fMRI studies.
- Subjects :
- Adult
Male
Psychosis
Schizophrenia (object-oriented programming)
Decision Making
Statistics as Topic
Mismatch negativity
Neuropsychological Tests
Electroencephalography
behavioral disciplines and activities
Developmental psychology
Mental Processes
Reaction Time
medicine
Humans
Theta Rhythm
Biological Psychiatry
Probability
Analysis of Variance
medicine.diagnostic_test
Cognition
Middle Aged
medicine.disease
Inhibition, Psychological
Psychiatry and Mental health
Electrophysiology
Delta Rhythm
Go/no go
Schizophrenia
Female
Schizophrenic Psychology
Psychology
Functional magnetic resonance imaging
Neuroscience
Photic Stimulation
psychological phenomena and processes
Subjects
Details
- ISSN :
- 09209964
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- Schizophrenia Research
- Accession number :
- edsair.doi.dedup.....5b593a3bda7dd91f14eab7ba8e2c01ed
- Full Text :
- https://doi.org/10.1016/j.schres.2009.09.036