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Photoresponsive hollow molecularly imprinted polymer for trace triamterene in biological samples
- Source :
- Materials Science and Engineering: C. 76:568-578
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- This paper reports a photoresponsive hollow molecularly imprinted polymer for the determination of trace triamterene in biological sample. The photoresponsive hollow molecularly imprinted polymer was prepared on sacrificial silica microspheres via surface imprinting technique through atom transfer radical polymerization using a novel water-soluble azobenzene derivative, 4-[(4-methacryloyloxy)phenylazo]-3,5-dimethyl benzenesulfonic acid, as the functional monomer, and the sacrificial silica core was subsequently removed using HF etching method with 1.25vol.% HF ethanolic solution. The morphologies and properties of the photoresponsive hollow molecularly imprinted polymer were further characterized and compared systematically with the corresponding photoresponsive surface molecularly imprinted polymer. Compared with surface imprinted polymer, the hollow material displayed higher binding capacity, better recognition ability, faster mass-transfer rate, and larger isomerization rate constants toward triamterene. The static binding properties of the imprinted materials were investigated under three irradiation conditions. The photoresponsive hollow molecularly imprinted polymer showed better specificity toward triamterene than its structural analogues (folic acid and caffeine) as examined by UV-vis and HPLC. The photoresponsive hollow molecularly imprinted polymer was utilized for the determination of trace triamterene in biological samples (human urine and serum) with advantages of simple sample pre-treatment, good recovery and good sensitivity.
- Subjects :
- Materials science
Polymers
Bioengineering
02 engineering and technology
010402 general chemistry
01 natural sciences
Polymerization
Molecular Imprinting
Biomaterials
chemistry.chemical_compound
Benzenesulfonic acid
Humans
chemistry.chemical_classification
Chromatography
Atom-transfer radical-polymerization
technology, industry, and agriculture
Molecularly imprinted polymer
Polymer
021001 nanoscience & nanotechnology
Microspheres
0104 chemical sciences
Azobenzene
chemistry
Chemical engineering
Mechanics of Materials
0210 nano-technology
Molecular imprinting
Isomerization
Triamterene
Subjects
Details
- ISSN :
- 09284931
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- Materials Science and Engineering: C
- Accession number :
- edsair.doi.dedup.....5b4e442cc44e8cf6a7049d1ec42e617a