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Prednisolone Promotes the Secretion of Progesterone and Oestradiol by Luteinised Granulosa Cells Independent of Human Chorionic Gonadotropin
- Source :
- Gynecologic and Obstetric Investigation. 29:188-191
- Publication Year :
- 1990
- Publisher :
- S. Karger AG, 1990.
-
Abstract
- An in vitro model based on luteinised granulosa cells gained during an in vitro fertilisation programme examines the question of whether prednisolone, and thus glucocorticoids in general, are capable of exerting an influence on the secretion of oestradiol and progesterone. It can be demonstrated that prednisolone leads to dosage-dependent increases in the concentration of both steroids, even independently of concurrent stimulation by human chorionic gonadotropin. A similar mechanism for aromatase activity of human adipose cells is suggested.
- Subjects :
- endocrine system
medicine.medical_specialty
medicine.drug_class
Prednisolone
media_common.quotation_subject
medicine.medical_treatment
Adipose tissue
In Vitro Techniques
Luteal Phase
Chorionic Gonadotropin
Human chorionic gonadotropin
Internal medicine
medicine
Humans
Aromatase
Ovulation
Progesterone
media_common
Granulosa Cells
Dose-Response Relationship, Drug
Estradiol
biology
Chemistry
Obstetrics and Gynecology
Steroid hormone
Endocrinology
Reproductive Medicine
Estrogen
biology.protein
Female
Gonadotropin
medicine.drug
Subjects
Details
- ISSN :
- 1423002X and 03787346
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Gynecologic and Obstetric Investigation
- Accession number :
- edsair.doi.dedup.....5b4da70ade613e2f8d33712b255dd7b8