Back to Search
Start Over
Anti-Helicobacter pylori effectiveness and targeted delivery performance of amoxicillin-UCCs-2/TPP nanoparticles based on ureido-modified chitosan derivative
- Source :
- International Journal of Biological Macromolecules. 115:367-374
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- The amoxicillin-UCCs-2/TPP nanoparticles constructed with ureido-modified chitosan derivative UCCs-2 and sodium tripolyphosphate (TPP) played an important role to deliver drug to achieve more efficacious and specific eradication of Helicobacterpylori (H. pylori) in vitro. In this study, the anti-H. pylori effectiveness in vivo and uptake mechanism was investigated in details, including the effect of temperature, pH values and the addition of competitive substrate urea on uptake. Compared with unmodified nanoparticles, a more efficacious and specific anti-H. pylori activities were obtained in vivo by using this biological chitosan derivative UCCs-2. Histological staining and immunological analysis verified that the amoxicillin-UCCs-2/TPP nanoparticles could diminish the proinflammatory cytokines levels and alleviate the inflammatory damages caused by H. pylori infection. The uredio-modified nanoparticles also have favorable gastric retention property, which is beneficial for the oral drug delivery to targeted eradicate H. pylori infection in stomach. These findings suggest that this targeted drug delivery system may serve for specific treatment of H. pylori infection both in vitro and in vivo, which can also be used as promising nanocarriers for other therapeutic reagents to target H. pylori.
- Subjects :
- Male
0301 basic medicine
Drug
media_common.quotation_subject
Pharmacology
Biochemistry
Helicobacter Infections
Proinflammatory cytokine
Mice
Structure-Activity Relationship
03 medical and health sciences
0302 clinical medicine
Polyphosphates
Structural Biology
In vivo
medicine
Animals
Urea
Molecular Biology
media_common
Chitosan
Drug Carriers
Mice, Inbred BALB C
Helicobacter pylori
biology
Chemistry
Stomach
Amoxicillin
Biological Transport
General Medicine
Hydrogen-Ion Concentration
biology.organism_classification
In vitro
Anti-Bacterial Agents
030104 developmental biology
Targeted drug delivery
Gastric Mucosa
030220 oncology & carcinogenesis
Cytokines
Nanoparticles
Nanocarriers
medicine.drug
Subjects
Details
- ISSN :
- 01418130
- Volume :
- 115
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Macromolecules
- Accession number :
- edsair.doi.dedup.....5b349423629034e6884bb3fdd7b7b966