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FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans

Authors :
Alan L. Patrick
Enrico Petretto
M. Fanciulli
Paul M. McKeigue
Timothy J. Aitman
Mariam Molokhia
Amy L. Roberts
Timothy J. Vyse
Source :
Molokhia, M, Fanciulli, M, Petretto, E, Patrick, A L, McKeigue, P, Roberts, A L, Vyse, T J & Aitman, T 2011, ' FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans ', Rheumatology, vol. 50, no. 7, pp. 1206-1210 . https://doi.org/10.1093/rheumatology/keq456
Publication Year :
2011

Abstract

OBJECTIVES: To evaluate FCGR3B copy number variation (CNV) in African and European populations and to determine if FCGR3B copy number is associated with SLE and SLE nephritis risk in Afro-Caribbeans, adjusting for African genetic ancestry. METHODS: We estimated FCGR3B to determine if there were ethnic variations in CNV (unrelated unadmixed Europeans and Africans). We then examined CNV at FCGR3B in relation to SLE and SLE nephritis within a case-control collection of 134 cases of SLE (37 with SLE nephritis) and 589 population controls of mainly Afro-Caribbean descent resident in Trinidad. RESULTS: We found a significant difference in copy number FCGR3B distribution between unadmixed African and European UK cohorts, with 27 (29%) vs 3 (5%) for those with low (0 or 1) copy FCGR3B, respectively, P = 0.002. In a Trinidadian SLE case-control study, low FCGR3B CNV was associated with SLE risk 1.7 (95% CI 1.1, 2.8), P = 0.02, which remained after adjustment for African genetic ancestry; odds ratios (ORs) 1.7 (95% CI 1.0, 2.8), P = 0.04. CONCLUSION: Our studies suggest that FCGR3B low copy number is associated with SLE risk in Afro-Caribbean populations independently of CNV due to African ancestry.

Details

ISSN :
14620332 and 14620324
Volume :
50
Issue :
7
Database :
OpenAIRE
Journal :
Rheumatology (Oxford, England)
Accession number :
edsair.doi.dedup.....5b33c2994841014855ea668360ffde24
Full Text :
https://doi.org/10.1093/rheumatology/keq456