Back to Search
Start Over
FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans
- Source :
- Molokhia, M, Fanciulli, M, Petretto, E, Patrick, A L, McKeigue, P, Roberts, A L, Vyse, T J & Aitman, T 2011, ' FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans ', Rheumatology, vol. 50, no. 7, pp. 1206-1210 . https://doi.org/10.1093/rheumatology/keq456
- Publication Year :
- 2011
-
Abstract
- OBJECTIVES: To evaluate FCGR3B copy number variation (CNV) in African and European populations and to determine if FCGR3B copy number is associated with SLE and SLE nephritis risk in Afro-Caribbeans, adjusting for African genetic ancestry. METHODS: We estimated FCGR3B to determine if there were ethnic variations in CNV (unrelated unadmixed Europeans and Africans). We then examined CNV at FCGR3B in relation to SLE and SLE nephritis within a case-control collection of 134 cases of SLE (37 with SLE nephritis) and 589 population controls of mainly Afro-Caribbean descent resident in Trinidad. RESULTS: We found a significant difference in copy number FCGR3B distribution between unadmixed African and European UK cohorts, with 27 (29%) vs 3 (5%) for those with low (0 or 1) copy FCGR3B, respectively, P = 0.002. In a Trinidadian SLE case-control study, low FCGR3B CNV was associated with SLE risk 1.7 (95% CI 1.1, 2.8), P = 0.02, which remained after adjustment for African genetic ancestry; odds ratios (ORs) 1.7 (95% CI 1.0, 2.8), P = 0.04. CONCLUSION: Our studies suggest that FCGR3B low copy number is associated with SLE risk in Afro-Caribbean populations independently of CNV due to African ancestry.
- Subjects :
- Male
AUTOIMMUNITY
Lupus nephritis
SLE
CCL3L1
SUSCEPTIBILITY
DISEASE
Cohort Studies
Polymorphism (computer science)
Reference Values
HUMAN GENOME
Lupus Erythematosus, Systemic
Pharmacology (medical)
Copy-number variation
skin and connective tissue diseases
POPULATION
education.field_of_study
Incidence
FCGR3B
Middle Aged
Prognosis
Lupus Nephritis
Caribbean Region
Female
Nephritis
EXPRESSION
Adult
medicine.medical_specialty
Adolescent
DNA Copy Number Variations
PREDISPOSES
Population
Black People
Admixture
GPI-Linked Proteins
Risk Assessment
White People
Article
Young Adult
Rheumatology
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
Genetic Testing
Risk factor
education
Aged
business.industry
Copy number variation
African
Receptors, IgG
Odds ratio
medicine.disease
GENE
POLYMORPHISM
Immunology
business
Subjects
Details
- ISSN :
- 14620332 and 14620324
- Volume :
- 50
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Rheumatology (Oxford, England)
- Accession number :
- edsair.doi.dedup.....5b33c2994841014855ea668360ffde24
- Full Text :
- https://doi.org/10.1093/rheumatology/keq456