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Prevalence of tubulopathy and association with renal function loss in HIV-infected patients
- Source :
- Nephrology Dialysis Transplantation, Nephrology Dialysis Transplantation, Oxford University Press (OUP), 2019, ⟨10.1093/ndt/gfz081⟩, Nephrol Dial Transplant
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Background The incidence of chronic kidney disease (CKD) is 10 times higher in human immunodeficiency virus (HIV)-infected patients than in the general population. We explored the prevalence and determinants of proximal tubular dysfunction (PTD) in HIV-infected individuals, and assessed the impact of the tubulopathy on the estimated glomerular filtration rate (eGFR) outcome. Methods A cohort study was performed on 694 outpatients followed in a French centre to analyse the prevalence of PTD, the diagnosis performance of screening tools and the associated factors. eGFR was prospectively evaluated to analyse the predictive value of the tubulopathy on eGFR decrease. Results At inclusion, 14% of the patients presented with PTD and 5% with CKD. No individual tubular marker, including non-glomerular proteinuria, glycosuria dipstick or hypophosphataemia, registered sufficient performance to identify PTD. We found a significant interaction between tenofovir disoproxil fumarate exposure and ethnicity (P = 0.03) for tubulopathy risk. Tenofovir disoproxil fumarate exposure was associated with PTD in non-Africans [adjusted odds ratio (aOR) = 4.71, P Conclusion PTD is not rare in HIV-infected individuals but is less frequent in sub-Saharan African patients and is associated with tenofovir disoproxil fumarate exposure only in non-Africans. Its diagnosis requires multiple biochemical testing and it is not associated with an accelerated eGFR decline.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
microalbuminuria
Anti-HIV Agents
Population
proximal tubule dysfunction
030232 urology & nephrology
Renal function
HIV Infections
urologic and male genital diseases
GFR
03 medical and health sciences
0302 clinical medicine
Tubulopathy
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Internal medicine
Prevalence
medicine
Humans
Prospective Studies
Renal Insufficiency, Chronic
Tenofovir
10. No inequality
education
Transplantation
education.field_of_study
Proteinuria
business.industry
Incidence (epidemiology)
Editorials
HIV
Odds ratio
Middle Aged
medicine.disease
030112 virology
3. Good health
Kidney Tubules
Nephrology
ethnicity
Female
Microalbuminuria
France
medicine.symptom
business
Biomarkers
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- ISSN :
- 14602385 and 09310509
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Nephrology Dialysis Transplantation
- Accession number :
- edsair.doi.dedup.....5b27c3d62e5588b7352328c259c0ce23