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Synthesis of N-doped carbon dots for highly selective and sensitive detection of metronidazole in real samples and its cytotoxicity studies
- Source :
- Environmental technology. 43(27)
- Publication Year :
- 2021
-
Abstract
- The current investigation reports the synthesis of N-CDs using glucosamine, ascorbic acid, and ethylenediamine precursors by a simple hydrothermal technique. The formation of N-CDs was proved by various characterisation techniques such as X-ray Photoelectron Spectroscopy (XPS), X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Fourier-Transform Infrared Spectrophotometer (FT-IR). The optical properties were investigated by fluorescence and UV-vis spectrophotometer. Also, N-CDs showed high selectivity in detecting the MTZ compared to several other analytes. However, the metronidazole serves as an antibiotic against several microbial diseases but also a genotoxic, carcinogenic to the human when used in excessive dosage. The synthesised N-CDs showed high selectivity in detecting the MTZ compared to several other analytes. Besides, the cytotoxicity of the N-CDs was studied to evaluate its toxicity against the HeLa cancer cells. It showed 65.6% cell viability and 34.3% toxicity against the cancerous cells, and similarly 71% of cells viability against H9C2 cells. Thus, the current investigation explores the promising selective sensing of N-CDs against MTZ, along with that, it proved its cytotoxicity against HeLa cancerous cells and non-toxicity against H9C2 cells. The synthesised CDs can be better MTZ sensors and anti-cancer agents on further development at the industrial scale.
- Subjects :
- 0208 environmental biotechnology
Infrared spectroscopy
Ethylenediamine
02 engineering and technology
010501 environmental sciences
01 natural sciences
HeLa
chemistry.chemical_compound
Metronidazole
Quantum Dots
Spectroscopy, Fourier Transform Infrared
Environmental Chemistry
Humans
Viability assay
Cytotoxicity
Waste Management and Disposal
0105 earth and related environmental sciences
Water Science and Technology
Fluorescent Dyes
biology
Chemistry
Photoelectron Spectroscopy
General Medicine
biology.organism_classification
Ascorbic acid
Fluorescence
Carbon
020801 environmental engineering
Cancer cell
Nuclear chemistry
Subjects
Details
- ISSN :
- 1479487X
- Volume :
- 43
- Issue :
- 27
- Database :
- OpenAIRE
- Journal :
- Environmental technology
- Accession number :
- edsair.doi.dedup.....5b1e2d635e740111a4fc6fcab365219f