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The Role of Exosomal Non-Coding RNAs in Coronary Artery Disease
- Source :
- Frontiers in Pharmacology, Frontiers in Pharmacology, Vol 11 (2020)
- Publication Year :
- 2020
- Publisher :
- Frontiers Media S.A., 2020.
-
Abstract
- Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Atherosclerosis (AS) is a major cause of CVD. Oxidative stress, endothelial dysfunction, and inflammation are key factors involved in the development and progression of AS. Exosomes are nano-sized vesicles secreted into the extracellular space by most types of cells, and are ideal substances for the transmission and integration of signals between cells. Cells can selectively encapsulate biologically active substances, such as lipids, proteins and RNA in exosomes and act through paracrine mechanisms. Non-coding RNAs (ncRNAs) are important for communication between cells. They can reach the recipient cells through exosomes, causing phenotypic changes and playing a molecular regulatory role in cell function. Elucidating their molecular mechanisms can help identify therapeutic targets or strategies for CVD. Coronary artery disease (CAD) is the most important disease in CVD. Here, we review the role and the regulatory mechanism of exosomal ncRNAs in the pathophysiology of CAD, as well as the potential contribution of exosomal ncRNA to diagnosis and treatment of CAD.
- Subjects :
- 0301 basic medicine
acute myocardial infarction
Inflammation
Disease
Review
exosomes
030204 cardiovascular system & hematology
Non-coding RNAs
03 medical and health sciences
0302 clinical medicine
medicine
Pharmacology (medical)
Endothelial dysfunction
Pharmacology
Mechanism (biology)
business.industry
lcsh:RM1-950
RNA
medicine.disease
Non-coding RNA
Phenotype
Microvesicles
lcsh:Therapeutics. Pharmacology
030104 developmental biology
Cancer research
medicine.symptom
atherosclerosis
business
coronary artery disease
Subjects
Details
- Language :
- English
- ISSN :
- 16639812
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Pharmacology
- Accession number :
- edsair.doi.dedup.....5b150ac34f0e937730a2fb5f0ba89bc0