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Helicobacter pylori infection and liver diseases: Epidemiology and insights into pathogenesis
- Source :
- World Journal of Gastroenterology
- Publication Year :
- 2018
- Publisher :
- Baishideng Publishing Group Inc, 2018.
-
Abstract
- Both Helicobacter pylori (H. pylori) infection and liver diseases, including nonalcoholic fatty liver disease (NAFLD), viral hepatitis, and hepatocellular carcinoma (HCC), have high prevalences worldwide, and the relationship between H. pylori infection and liver disease has been discussed for many years. Although positive correlations between H. pylori and NAFLD have been identified in some clinical and experimental studies, negative correlations have also been obtained in high-quality clinical studies. Associations between H. pylori and the pathogenesis of chronic viral hepatitis, mainly disease progression with fibrosis, have also been suggested in some clinical studies. Concerning HCC, a possible role for H. pylori in hepatocarcinogenesis has been identified since H. pylori genes have frequently been detected in resected HCC specimens. However, no study has revealed the direct involvement of H. pylori in promoting the development of HCC. Although findings regarding the correlations between H. pylori and liver disease pathogenesis have been accumulating, the existing data do not completely lead to an unequivocal conclusion. Further high-quality clinical and experimental analyses are necessary to evaluate the efficacy of H. pylori eradication in ameliorating the histopathological changes observed in each liver disease.
- Subjects :
- medicine.medical_specialty
Hepatitis B virus
Hepatocellular carcinoma
Hepatitis C virus
Review
medicine.disease_cause
Gastroenterology
Pathogenesis
03 medical and health sciences
Liver disease
0302 clinical medicine
Internal medicine
Nonalcoholic fatty liver disease
medicine
Nonalcoholic steatohepatitis
Viral hepatitis
biology
Helicobacter pylori
business.industry
General Medicine
medicine.disease
biology.organism_classification
bacterial infections and mycoses
digestive system diseases
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
business
Subjects
Details
- Language :
- English
- ISSN :
- 22192840 and 10079327
- Volume :
- 24
- Issue :
- 32
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....5b085ad9d328596cf2dbccbf429befb8