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Acetate: inhibitor of growth hormone hypersecretion in diabetic and non-diabetic uraemic subjects
- Source :
- Acta Endocrinologica. 99:551-558
- Publication Year :
- 1982
- Publisher :
- Oxford University Press (OUP), 1982.
-
Abstract
- Five diabetic and 14 non-diabetic uraemic patients on long-term haemodialysis were studied during twenty-one 24 h periods including 5 to 7 h of haemodialysis against glucose-free acetate buffered dialysis fluid. Half-hourly blood samples were collected for hormonal and metabolite analysis. In addition, blood samples were analyzed in 40 experiments covering the haemodialysis and a pre-dialysis period. Before dialysis, plasma growth hormone levels were high and fluctuating, but almost always fell to low normal values within the first 2 h of haemodialysis. In the diabetic uraemic patients, the occasional severe hypoglycaemic episodes occurring during haemodialysis did not provoke growth hormone release, and hypoglycaemic reactions were not encountered. Intravenous acetate infusion studies resulted in plasma concentrations ranging from 1.3 to 2.7 mmol, i.e. about 60 per cent of the levels reached during haemodialysis and in suppression of growth hormone secretion. It is suggested that the fall in growth hormone levels and the lack of hypoglycaemic symptoms during haemodialysis is due to the use of acetate as a fuel in brain.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Acetates
Hypoglycemia
Growth hormone
Endocrinology
Renal Dialysis
Internal medicine
Diabetes mellitus
medicine
Humans
Dialysis
Uremia
Heparin
business.industry
General Medicine
Middle Aged
medicine.disease
Growth hormone secretion
Diabetes Mellitus, Type 1
Growth Hormone
Female
business
medicine.drug
Hormone
Subjects
Details
- ISSN :
- 1479683X and 08044643
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Acta Endocrinologica
- Accession number :
- edsair.doi.dedup.....5afc102c55a1f6eefa1c9f1eb724dc37