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Tin, Titanium, Tantalum, Vanadium and Niobium Oxide Based Sensors to Detect Colorectal Cancer Exhalations in Blood Samples
- Source :
- Molecules, Volume 26, Issue 2, Molecules, Vol 26, Iss 466, p 466 (2021)
- Publication Year :
- 2021
-
Abstract
- User-friendly, low-cost equipment for preventive screening of severe or deadly pathologies are one of the most sought devices by the National Health Services, as they allow early disease detection and treatment, often avoiding its degeneration. In recent years more and more research groups are developing devices aimed at these goals employing gas sensors. Here, nanostructured chemoresistive metal oxide (MOX) sensors were employed in a patented prototype aimed to detect volatile organic compounds (VOCs), exhaled by blood samples collected from patients affected by colorectal cancer and from healthy subjects as a control. Four sensors, carefully selected after many years of laboratory tests on biological samples (cultured cells, human stools, human biopsies, etc.), were based here on various percentages of tin, tungsten, titanium, niobium, tantalum and vanadium oxides. Sensor voltage responses were statistically analyzed also with the receiver operating characteristic (ROC) curves, that allowed the identification of the cut-off discriminating between healthy and tumor affected subjects for each sensor, leading to an estimate of sensitivity and specificity parameters. ROC analysis demonstrated that sensors employing tin and titanium oxides decorated with gold nanoparticles gave sensitivities up to 80% yet with a specificity of 70%.
- Subjects :
- Male
Adult
Materials science
Colorectal cancer
chemoresistivity
Niobium
Tantalum
Pharmaceutical Science
chemistry.chemical_element
Vanadium
Metal Nanoparticles
colorectal cancer
02 engineering and technology
Article
Analytical Chemistry
NO
lcsh:QD241-441
03 medical and health sciences
blood, chemoresistivity, colorectal cancer, nanostructured sensors, tumor markers, volatile organic compounds, Adult, Colorectal Neoplasms, Metal Nanoparticles, Niobium, Vanadium, Tantalum, Tin
0302 clinical medicine
lcsh:Organic chemistry
blood
volatile organic compounds
Drug Discovery
medicine
Niobium oxide
Humans
Physical and Theoretical Chemistry
nanostructured sensors
Receiver operating characteristic
Organic Chemistry
021001 nanoscience & nanotechnology
medicine.disease
chemistry
Chemistry (miscellaneous)
tumor markers
Tin
030220 oncology & carcinogenesis
Molecular Medicine
Female
Microscopy, Electrochemical, Scanning
0210 nano-technology
Colorectal Neoplasms
Biomedical engineering
Titanium
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Molecules, Volume 26, Issue 2, Molecules, Vol 26, Iss 466, p 466 (2021)
- Accession number :
- edsair.doi.dedup.....5aef30b9d21f7db09615bc3be9eaa6dd