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Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis
- Source :
- Science (New York, N.Y.). 373(6561)
- Publication Year :
- 2021
-
Abstract
- Defining tumor cell immune evasion Mouse models used to study cancer often lack a full immune system, allowing implantation of human tumors into the mice. By contrast, naturally evolving tumors must contend with a fully functional immune system and its destruction of some of the cells (see the Perspective by Ho and Wood). Two groups now report studies on mouse models with a fully intact immune system. Martin et al . started with preexisting murine tumor cell lines and examined their continued evolution in vivo, whereas Del Poggetto et al . examined the development of new pancreatic tumors in the context of inflammation, as is often seen in human patients. In each study, the authors found that the immune system exerted a selective pressure on cells that would give rise to tumors, promoting the survival of those that had lost expression of tumor suppressor genes or activated a specific oncogene. The findings suggest a major role for the immune system in driving tumor evolution across multiple types of cancer. —YN
- Subjects :
- Male
Carcinogenesis
MAP Kinase Signaling System
Context (language use)
Inflammation
Acinar Cells
medicine.disease_cause
Epigenesis, Genetic
Mice
Metaplasia
Spheroids, Cellular
Carcinoma
medicine
Animals
Pancreas
Cells, Cultured
Early Growth Response Protein 1
Mutation
Enzyme Precursors
Multidisciplinary
business.industry
Epithelial Cells
medicine.disease
Cellular Reprogramming
Chromatin
Cell Transformation, Neoplastic
Genes, ras
Pancreatitis
Cancer research
Female
KRAS
medicine.symptom
business
Transcriptome
Carcinoma, Pancreatic Ductal
Subjects
Details
- ISSN :
- 10959203
- Volume :
- 373
- Issue :
- 6561
- Database :
- OpenAIRE
- Journal :
- Science (New York, N.Y.)
- Accession number :
- edsair.doi.dedup.....5ae7db9c38a42017638d5f6223c414e9