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Univariate and multivariate analyses of preoperative factors influencing symptomatic outcomes of transoral fundoplication
- Source :
- Surgical Endoscopy
- Publisher :
- Springer Nature
-
Abstract
- Background Preoperative factors predicting symptomatic improvement after transoral fundoplication (TF) in chronic gastroesophageal reflux disease (GERD) patients with persistent symptoms on proton-pump inhibitors (PPIs) therapy have not been elucidated fully. Methods Univariate and multivariate logistic regression analyses were performed on data from 158 consecutive patients who underwent TF with the EsophyX device between January 2010 and June 2012 in 14 community centers. Variables included age, gender, body mass index, GERD duration, PPIs therapy duration, presence of hiatal hernia, esophagitis, Hill grade, quality of life scores (QOL) on PPIs, % total time pH 13 on PPIs (OR = 2.4, CI = 1.1–5.2, p = 0.027), and Gastroesophageal Reflux Symptom Score ≥ 18 on PPIs (OR = 2.6, CI = 1.2–5.8, p = 0.018). Age and GERD-HRQL score remained significant predictors by multivariate analysis. For patients with atypical symptoms, only GERD-HRQL score ≥ 15 on PPIs (OR = 9.9, CI = 0.9–4.6, p = 0.036) was associated with successful outcomes. Conclusions Elevated preoperative QOL scores on PPIs and age ≥ 50 were most closely associated with successful outcome of TF in patients with persistent symptoms despite medical therapy.
- Subjects :
- Male
Multivariate analysis
Fundoplication
Gastroenterology
Heartburn
Recurrence
Esophagitis
Prospective Studies
Laparoscopy
Prospective cohort study
Aged, 80 and over
medicine.diagnostic_test
Age Factors
Regurgitation
Middle Aged
humanities
Treatment Outcome
Gastroesophageal reflux
Female
medicine.symptom
Adult
Reoperation
EsophyX
medicine.medical_specialty
Article
Young Adult
Esophagus
Internal medicine
medicine
Humans
Hernia
Aged
Refractory
business.industry
Proton Pump Inhibitors
GERD
Hepatology
TIF
medicine.disease
digestive system diseases
Surgery
Hernia, Hiatal
Multivariate Analysis
Quality of Life
business
Abdominal surgery
Subjects
Details
- Language :
- English
- ISSN :
- 09302794
- Volume :
- 28
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Surgical Endoscopy
- Accession number :
- edsair.doi.dedup.....5ae5af5b1649597ddf15c507b839aedd
- Full Text :
- https://doi.org/10.1007/s00464-014-3557-z