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NIST interlaboratory studies involving DNA mixtures (MIX05 and MIX13): Variation observed and lessons learned
- Source :
- Forensic Science International: Genetics. 37:81-94
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Interlaboratory studies are a type of collaborative exercise in which many laboratories are presented with the same set of data to interpret, and the results they produce are examined to get a "big picture" view of the effectiveness and accuracy of analytical protocols used across participating laboratories. In 2005 and again in 2013, the Applied Genetics Group of the National Institute of Standards and Technology (NIST) conducted interlaboratory studies involving DNA mixture interpretation. In the 2005 NIST MIX05 study, 69 laboratories interpreted data in the form of electropherograms of two-person DNA mixtures representing four different mock sexual assault cases with different contributor ratios. In the 2013 NIST MIX13 study,108 laboratories interpreted electropherogram data for five different case scenarios involving two, three, or four contributors, with some of the contributors potentially related. This paper describes the design of these studies, the variations observed among laboratory results, and lessons learned.
- Subjects :
- Electrophoresis
Forensic Genetics
Male
0301 basic medicine
Canada
Computer science
Polymerase Chain Reaction
Pathology and Forensic Medicine
03 medical and health sciences
Forensic dna
Government Agencies
0302 clinical medicine
Genetics
Humans
030216 legal & forensic medicine
Alleles
Sexual assault
Sex Offenses
DNA
Laboratory results
DNA Fingerprinting
Data science
United States
Electropherogram
030104 developmental biology
NIST
Female
Laboratories
Microsatellite Repeats
Subjects
Details
- ISSN :
- 18724973
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Forensic Science International: Genetics
- Accession number :
- edsair.doi.dedup.....5ae1404b72119c6bf3e190a86db42711