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Improved Anticancer Activity of the Malloapelta B-Nanoliposomal Complex against Lung Carcinoma
- Source :
- Applied Sciences, Vol 10, Iss 8148, p 8148 (2020), Applied Sciences, Volume 10, Issue 22
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Previous studies regarding malloapelta B (malB), a natural compound isolated from the Vietnamese medicinal plant, showed a strong NF-&kappa<br />B inhibitory effect, making it a promising source for the development of novel anticancer drugs. However, similar to many other natural compounds from plants, malB has several disadvantages for clinical applications, including high toxicity and low solubility. To improve its bioavailability, malB was conjugated into nanoliposomes, which are ideal drug carriers. The formulations with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, mPEG-cholesterol, malB, with or without cholesterol exhibited nanoliposomes with an average diameter of approximately 76.98 nm, PDI of 0.28, zeta potential of &minus<br />5.53 mV, and the highest encapsulation efficiency of 78.73% &plusmn<br />9.5%. These malB-nanoliposomes inhibited the survival of all lung cancer cell lines examined with IC50 values ranging from 11.86 to 13.12 &micro<br />M. Moreover, malB-nanoliposomes showed stronger inhibition of A549 colony-forming activity compared to that of the free compound. The effects of malB and its nanoliposomal formulation may be mediated through activation of apoptosis by the significant induction of caspase 3 activity. The nanoliposomal formulations also showed potential to inhibit tumor growth (37.03%) and prolong survival (32.20 days) of tumor-bearing mice compared with the unloaded drug (p &lt<br />0.05). The improved antitumor activity of malB-nanoliposomes suggests their promising clinical applications.
- Subjects :
- Drug
media_common.quotation_subject
nanoliposome
Caspase 3
02 engineering and technology
Pharmacology
lcsh:Technology
lcsh:Chemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
caspase 3
General Materials Science
Instrumentation
lcsh:QH301-705.5
media_common
malloapelta B
Fluid Flow and Transfer Processes
Cholesterol
lcsh:T
Process Chemistry and Technology
General Engineering
apoptosis
Lewis lung carcinoma
021001 nanoscience & nanotechnology
lcsh:QC1-999
Computer Science Applications
Bioavailability
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Apoptosis
lcsh:TA1-2040
030220 oncology & carcinogenesis
Toxicity
0210 nano-technology
Drug carrier
lcsh:Engineering (General). Civil engineering (General)
lcsh:Physics
Subjects
Details
- Language :
- English
- ISSN :
- 20763417
- Volume :
- 10
- Issue :
- 8148
- Database :
- OpenAIRE
- Journal :
- Applied Sciences
- Accession number :
- edsair.doi.dedup.....5adc995ffaf9267826eb13a94b610072