Back to Search
Start Over
Smart magnetic resonance imaging agents that sense extracellular calcium fluctuations
- Source :
- ChemBioChem, ChemBioChem, Wiley-VCH Verlag, 2008, 9 (11), pp.1729-34. ⟨10.1002/cbic.200800165⟩, ChemBioChem: A European Journal of Chemical Biology
- Publication Year :
- 2008
-
Abstract
- Gd3+ chelates linked to a modified EGTA moiety were prepared in order to respond to extracellular Ca2+ fluctuations in the brain Gd3+ chelates linked to a modified EGTA moiety were prepared in order to respond to extracellular Ca2+ fluctuations in the brain. Upon interaction with Ca2+, they exhibit high and reversible relaxivity changes in buffered solution or in a model of the brain extracellular medium. These efficient Ca2+ magnetic resonance imaging sensors might open new perspectives in functional molecular imaging.
- Subjects :
- Physics of magnetic resonance imaging
Gadolinium
chemistry.chemical_element
Calcium
010402 general chemistry
01 natural sciences
Biochemistry
Sensitivity and Specificity
MESH: Titrimetry
MESH: Magnetic Resonance Imaging
chemistry.chemical_compound
Nuclear magnetic resonance
medicine
Extracellular
Organometallic Compounds
Moiety
Humans
Molecular Biology
MESH: Humans
medicine.diagnostic_test
010405 organic chemistry
Organic Chemistry
Titrimetry
MESH: Organometallic Compounds
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology
Magnetic resonance imaging
Magnetic Resonance Imaging
MESH: Sensitivity and Specificity
0104 chemical sciences
imaging agents
MESH: Extracellular Space
EGTA
chemistry
MESH: Calcium
Molecular Medicine
Molecular imaging
MESH: Gadolinium
Extracellular Space
Subjects
Details
- ISSN :
- 14397633 and 14394227
- Volume :
- 9
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Chembiochem : a European journal of chemical biology
- Accession number :
- edsair.doi.dedup.....5ad15722b6fef3958c1615bcbd6e67e3