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LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study
- Source :
- BMC Cancer, BMC Cancer, Vol 20, Iss 1, Pp 1-8 (2020)
- Publication Year :
- 2020
- Publisher :
- Research Square Platform LLC, 2020.
-
Abstract
- Background LncRNA MEG3 expressed abnormally in various cancers including breast cancer, but no studies reported the correlation between MEG3 SNPs and breast cancer susceptibility among Chinese women. Methods This study is aimed to explore the association between three SNPs of MEG3 (rs3087918, rs7158663, rs11160608) and breast cancer. The study is a population-based case-control study including 434 breast cancer patients and 700 healthy controls. Genotyping was performed using Sequenom MassArray technique. Function prediction of rs3087918 were based on RNAfold and lncRNASNP2 databases. Results Pooled analysis indicated that rs3087918 was related to a decreased risk of breast cancer [GG vs. TT: OR (95%) = 0.67(0.45–0.99), P = 0.042; GG vs. TT + TG: OR (95%) = 0.69(0.48–0.99), P = 0.046], especially for women aged P = 0.02]. Comparison between case groups showed genotype GG and TG/GG of rs3087918 were associated with her-2 receptor expression [GG vs. TT: OR (95%) = 2.37(1.24–4.63), P = 0.010; TG + GG vs. TT: OR (95%) = 1.50(1.01–2.24), P = 0.045]. We didn’t find statistical significance for rs11160608, rs7158663 and breast cancer. Structure prediction based on RNAfold found rs3087918 may influence the secondary structure of MEG3. The results based on lncRNASNP2 indicated that rs3087918 may gain the targets of hsa-miR-1203 to MEG3, while loss the target of hsa-miR-139-3p and hsa-miR-5091 to MEG3. Conclusions MEG3 rs3087918 was associated with a decreased risk of breast cancer. MEG3 haplotype TCG may increase the risk of breast cancer.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
Genotyping Techniques
Receptor expression
Breast cancer
0302 clinical medicine
Surgical oncology
Genotype
Breast
education.field_of_study
Case-control study
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Healthy Volunteers
Gene Expression Regulation, Neoplastic
030220 oncology & carcinogenesis
Female
RNA, Long Noncoding
Research Article
Adult
medicine.medical_specialty
Population
SNP
Breast Neoplasms
Single-nucleotide polymorphism
lcsh:RC254-282
Polymorphism, Single Nucleotide
03 medical and health sciences
Statistical significance
Internal medicine
Genetics
medicine
Humans
Genetic Predisposition to Disease
MEG3
education
miRNA
Aged
Neoplasm Staging
business.industry
Protective Factors
medicine.disease
MicroRNAs
030104 developmental biology
Haplotypes
Case-Control Studies
Nucleic Acid Conformation
business
Subjects
Details
- ISSN :
- 11160608
- Database :
- OpenAIRE
- Journal :
- BMC Cancer, BMC Cancer, Vol 20, Iss 1, Pp 1-8 (2020)
- Accession number :
- edsair.doi.dedup.....5acdfa51d6c9e99a2d35da5efacacd1e