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Double barrier as an effective method for slower delivery rate of ibuprofen
- Source :
- International Journal of Pharmaceutics. 472:248-250
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Ibuprofen (IBU) was chosen as a model drug to investigate the drug delivery rate. Mesoporous MCM-41 has been charged with ibuprofen (MCM-41_IBU). Calcium alginate was applied to encapsulate free drug and the mesoporous material. The system with double barrier demonstrated a slower release of IBU than free ibuprofen-loaded alginate beads and MCM-41_IBU. The IBU release from alginate matrix can be controlled by adjusting the free IBU/MCM-41_IBU ratio.
- Subjects :
- Drug
Calcium alginate
Alginates
media_common.quotation_subject
Pharmaceutical Science
Ibuprofen
Double barrier
chemistry.chemical_compound
Drug Delivery Systems
Glucuronic Acid
MCM-41
medicine
media_common
Chromatography
Chemistry
Hexuronic Acids
organic chemicals
Anti-Inflammatory Agents, Non-Steroidal
Hydrogels
Silicon Dioxide
Controlled release
Drug Liberation
Chemical engineering
Drug delivery
Mesoporous material
medicine.drug
Subjects
Details
- ISSN :
- 03785173
- Volume :
- 472
- Database :
- OpenAIRE
- Journal :
- International Journal of Pharmaceutics
- Accession number :
- edsair.doi.dedup.....5abb4dc9454c769ad15eeec7e73df9b5