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Diabetic Retinopathy: Vascular and Inflammatory Disease

Authors :
Roberto dell'Omo
Francesco Semeraro
Anna Cancarini
Ciro Costagliola
Mario R. Romano
Sara Rezzola
Source :
Journal of Diabetes Research, Journal of Diabetes Research, Vol 2015 (2015)
Publication Year :
2015
Publisher :
Hindawi Limited, 2015.

Abstract

Diabetic retinopathy (DR) is the leading cause of visual impairment in the working-age population of the Western world. The pathogenesis of DR is complex and several vascular, inflammatory, and neuronal mechanisms are involved. Inflammation mediates structural and molecular alterations associated with DR. However, the molecular mechanisms underlying the inflammatory pathways associated with DR are not completely characterized. Previous studies indicate that tissue hypoxia and dysregulation of immune responses associated with diabetes mellitus can induce increased expression of numerous vitreous mediators responsible for DR development. Thus, analysis of vitreous humor obtained from diabetic patients has made it possible to identify some of the mediators (cytokines, chemokines, and other factors) responsible for DR pathogenesis. Further studies are needed to better understand the relationship between inflammation and DR. Herein the main vitreous-related factors triggering the occurrence of retinal complication in diabetes are highlighted.

Details

ISSN :
23146753 and 23146745
Volume :
2015
Database :
OpenAIRE
Journal :
Journal of Diabetes Research
Accession number :
edsair.doi.dedup.....5ab3782454895dd84125c5da718a5218
Full Text :
https://doi.org/10.1155/2015/582060