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Diabetic Retinopathy: Vascular and Inflammatory Disease
- Source :
- Journal of Diabetes Research, Journal of Diabetes Research, Vol 2015 (2015)
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- Diabetic retinopathy (DR) is the leading cause of visual impairment in the working-age population of the Western world. The pathogenesis of DR is complex and several vascular, inflammatory, and neuronal mechanisms are involved. Inflammation mediates structural and molecular alterations associated with DR. However, the molecular mechanisms underlying the inflammatory pathways associated with DR are not completely characterized. Previous studies indicate that tissue hypoxia and dysregulation of immune responses associated with diabetes mellitus can induce increased expression of numerous vitreous mediators responsible for DR development. Thus, analysis of vitreous humor obtained from diabetic patients has made it possible to identify some of the mediators (cytokines, chemokines, and other factors) responsible for DR pathogenesis. Further studies are needed to better understand the relationship between inflammation and DR. Herein the main vitreous-related factors triggering the occurrence of retinal complication in diabetes are highlighted.
- Subjects :
- angiogenesis
diabetes mellitus
diabetic retinopathy
disease course
hypoxemia
immune dysregulation
inflammatory disease
innate immunity
Blood Glucose
Chemokine
Endocrinology, Diabetes and Metabolism
Endocrinology
Population
Inflammation
Review Article
Disease
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Retina
Pathogenesis
Immune system
Diabetes mellitus
medicine
Humans
Hypoxia
education
education.field_of_study
lcsh:RC648-665
Diabetic Retinopathy
biology
business.industry
Retinal Vessels
Diabetic retinopathy
medicine.disease
Mitochondria
Diabetes and Metabolism
Oxidative Stress
Immunology
biology.protein
Cytokines
medicine.symptom
business
Subjects
Details
- ISSN :
- 23146753 and 23146745
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Research
- Accession number :
- edsair.doi.dedup.....5ab3782454895dd84125c5da718a5218
- Full Text :
- https://doi.org/10.1155/2015/582060